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A key feature of the movement to create more entrepreneurial universities is incentivizing researchers to move discoveries beyond the laboratory and into society. This places additional expectations on Ph.D. students and faculty in science and engineering disciplines, who are encouraged to explore the commercialization of their research to promote the role of universities in innovation and job creation. A major barrier to this movement is that traditional Ph.D. training does not prepare researchers to participate in entrepreneurial activity, and as such its relevance to scientific work may not be evident. In this paper, we propose a course model for science and technology entrepreneurship education that has been designed to enable academic researchers to play a more active and informed role in the commercialization of their discovery. Its curricular foundation is a set of 14 factors that address the following four priorities: (1) technology readiness and timing, (2) intellectual property pathway decisions, (3) engagement with the entrepreneurial ecosystem, and (4) personal career choices. We describe the rationale for the course, its content and outcomes. 

Living 3D in vitro tissue cultures, grown from immortalized cell lines, act as living sentinels as pathogenic bacteria invade the tissue. The infection is reported through changes in the intracellular dynamics of the sentinel cells caused by the disruption of normal cellular function by the infecting bacteria. Here, the Doppler imaging of infected sentinels shows the dynamic characteristics of infections. InvasiveSalmonella entericaserovar Enteritidis andListeria monocytogenespenetrate through multicellular tumor spheroids, while non-invasive strains ofEscherichia coliandListeria innocuaremain isolated outside the cells, generating different Doppler signatures. Phase distributions caused by intracellular transport display Lévy statistics, introducing a Lévy-alpha spectroscopy of bacterial invasion. Antibiotic treatment of infected spheroids, monitored through time-dependent Doppler shifts, can distinguish drug-resistant relative to non-resistant strains. This use of intracellular Doppler spectroscopy of living tissue sentinels opens a new class of microbial assay with potential importance for studying the emergence of antibiotic resistance.