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Abstract The discovery and localization of FRB 20240209A by the Canadian Hydrogen Intensity Mapping Fast Radio Burst (CHIME/FRB) experiment marks the first repeating FRB localized with the CHIME/FRB Outriggers and adds to the small sample of repeating FRBs with associated host galaxies. Here we present Keck and Gemini observations of the host that reveal a redshiftz = 0.1384 ± 0.0004. We perform stellar population modeling to jointly fit the optical through mid-IR data of the host and infer a median stellar mass log(M_*/M_⊙) = 11.35 ± 0.01 and a mass-weighted stellar population age  ~11 Gyr, corresponding to the most massive and oldest FRB host discovered to date. Coupled with a star formation rate  <0.31M_⊙yr⁻¹, the specific star formation rate  <10^−11.9yr⁻¹classifies the host as quiescent. Through surface brightness profile modeling, we determine an elliptical galaxy morphology, marking the host as the first confirmed elliptical FRB host. The discovery of a quiescent early-type host galaxy within a transient class predominantly characterized by late-type star-forming hosts is reminiscent of short-duration gamma-ray bursts, Type Ia supernovae, and ultraluminous X-ray sources. Based on these shared host demographics, coupled with a large offset as demonstrated in our companion Letter, we conclude that preferred sources for FRB 20240209A include magnetars formed through merging binary neutron stars/white dwarfs or the accretion-induced collapse of a white dwarf, or a luminous X-ray binary. Together with FRB 20200120E localized to a globular cluster in M81, our findings provide strong evidence that some fraction of FRBs may arise from a process distinct from the core collapse of massive stars. 

Abstract The Canadian Hydrogen Intensity Mapping Experiment (CHIME) has emerged as the prime telescope for detecting fast radio bursts (FRBs). CHIME/FRB Outriggers will be a dedicated very-long-baseline interferometry (VLBI) instrument consisting of outrigger telescopes at continental baselines working with CHIME and its specialized real-time transient-search backend (CHIME/FRB) to detect and localize FRBs with 50 mas precision. In this paper, we present a minimally invasive clock stabilization system that effectively transfers the CHIME digital backend reference clock from its original GPS-disciplined ovenized crystal oscillator to a passive hydrogen maser. This enables us to combine the long-term stability and absolute time tagging of the GPS clock with the short- and intermediate-term stability of the maser to reduce the clock timing errors between VLBI calibration observations. We validate the system with VLBI-style observations of Cygnus A over a 400 m baseline between CHIME and the CHIME Pathfinder, demonstrating agreement between sky-based and maser-based timing measurements at the 30 ps rms level on timescales ranging from one minute to up to nine days, and meeting the stability requirements for CHIME/FRB Outriggers. In addition, we present an alternate reference clock solution for outrigger stations that lack the infrastructure to support a passive hydrogen maser. 

The role of radiation-induced bystander effects in radiation therapy remains unclear. With renewed interest in therapy with alpha-particle emitters, and their potential for sterilizing disseminated tumor cells (DTCs), it is critical to determine the contribution of bystander effects to the overall response so they can be leveraged for maximum clinical benefit. Methods: Female Foxn1(nu) athymic nude mice were administered 0, 50, or 600 kBq/kg (RaCl2)-Ra-223 to create bystander conditions. At 24 hours after administration, MDA-MB-231 or MCF-7 human breast cancer cells expressing luciferase were injected into the tibial marrow compartment. Tumor burden was tracked weekly via bioluminescence. Results: The MDA-MB-231 xenografts were observed to have a 10-day growth delay in the 600 kBq/kg treatment group only. In contrast, MCF-7 cells had 7-and 65-day growth delays in the 50 and 600 kBq/kg groups, respectively. Histologic imaging of the tibial marrow compartment, alpha-camera imaging, and Monte Carlo dosimetry modeling revealed DTCs both within and beyond the range of the alpha-particles emitted from Ra-223 in bone for both MCF-7 and MDA-MB-231 cells. Conclusion: Taken together, these results support the participation of Ra-22(3)-induced antiproliferative/cytotoxic bystander effects in delayed growth of DTC xenografts. They indicate that the delay depends on the injected activity and therefore is dose-dependent. They suggest using (RaCl2)-Ra-223 as an adjuvant treatment for select patients at early stages of breast cancer. 

Abstract We search for gravitational-wave (GW) transients associated with fast radio bursts (FRBs) detected by the Canadian Hydrogen Intensity Mapping Experiment Fast Radio Burst Project, during the first part of the third observing run of Advanced LIGO and Advanced Virgo (2019 April 1 15:00 UTC–2019 October 1 15:00 UTC). Triggers from 22 FRBs were analyzed with a search that targets both binary neutron star (BNS) and neutron star–black hole (NSBH) mergers. A targeted search for generic GW transients was conducted on 40 FRBs. We find no significant evidence for a GW association in either search. Given the large uncertainties in the distances of our FRB sample, we are unable to exclude the possibility of a GW association. Assessing the volumetric event rates of both FRB and binary mergers, an association is limited to 15% of the FRB population for BNS mergers or 1% for NSBH mergers. We report 90% confidence lower bounds on the distance to each FRB for a range of GW progenitor models and set upper limits on the energy emitted through GWs for a range of emission scenarios. We find values of order 10⁵¹–10⁵⁷erg for models with central GW frequencies in the range 70–3560 Hz. At the sensitivity of this search, we find these limits to be above the predicted GW emissions for the models considered. We also find no significant coincident detection of GWs with the repeater, FRB 20200120E, which is the closest known extragalactic FRB.