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Abstract Image-based computational hemodynamics (ICH) employs medical imaging data to model and simulate patient-specific blood flow. Uncertainties arising from image noise, segmentation inaccuracies, and boundary condition modeling can significantly affect simulation outcomes. This study uses a case study to demonstrate the impact of image segmentation uncertainty and outlet boundary condition variability in ICH of blood flow within a human iliac arterial system reconstructed from CT angiography. To address challenges from high dimensionality and limited image data, the Uncertainty Separation Method is applied to decompose the simulation model into image segmentation and numerical submodels, enabling uncertainty estimations at the average 3D shape and mean numerical inputs. An alignment method is introduced to compute the average 3D anatomy from multiple segmented samples. Results show that this alignment method is essential for statistical analysis of image-based vascular shapes, and that image uncertainty, especially with limited samples, strongly influences the simulation outcomes. 

Abstract Predicting system reliability is often a core task in systems design. System reliability depends on component reliability and dependence of components. Component reliability can be predicted with a physics-based approach if the associated physical models are available. If the models do not exist, component reliability may be estimated from data. When both types of components coexist, their dependence is often unknown, and therefore, the component states are assumed independent by the traditional method, which can result in a large error. This study proposes a new system reliability method to recover the missing component dependence, thereby leading to a more accurate estimate of the joint probability density function (PDF) of all the component states. The method works for series systems whose load is shared by its components that may fail due to excessive loading. For components without physical models available, the load data are recorded upon failure, and equivalent physical models are created; the model parameters are estimated by the proposed Bayesian approach. Then models of all component states become available, and the dependence of component states, as well as their joint PDF, can be estimated. Four examples are used to evaluate the proposed method, and the results indicate that the method can produce more accurate predictions of system reliability than the traditional method that assumes independent component states. 

Abstract Predicting system reliability is often a core task in systems design. System reliability depends on component reliability and dependence of components. Component reliability can be predicted with a physics-based approach if the associated physical models are available. If the models do not exist, component reliability may be estimated from data. When both types of components coexist, their dependence is often unknown, and the component states are therefore assumed independent by the traditional method, which can result in a large error. This work proposes a new system reliability method to recover the missing component dependence, thereby leading to a more accurate estimate of the joint probability density (PDF) of all the component states. The method works for series systems whose load is shared by its components that may fail due to excessive loading. For components without physical models available, the load data are recorded upon failure, and equivalent physical models are created; the model parameters are estimated by the proposed Bayesian approach. Then models of all component states become available, and the dependence of component states, as well as their joint PDF, can be estimated. Four examples are used to evaluate the proposed method, and the results indicate that the proposed method can produce more accurate predictions of system reliability than the traditional method that assumes independent component states.