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After decades of development, flow-based microfluidic biochips have become an increasingly attractive platform for biochemical experiments. The fluid transportation and the on-chip device operation are controlled by microvalves, which are driven by external pneumatic controllers. To meet the increasingly complex experimental demands, the number of microvalves has significantly increased, making it necessary to adopt multiplexers (MUXes) for the actuation of microvalves. However, existing MUX designs have limited coding capacities, resulting in area overhead and excessive chip-to-world interface. This paper proposes a novel gate structure for modifying the current MUX architecture, along with a mixed coding strategy that achieves the maximum coding capacity within the modified MUX architecture. Additionally, an efficient synthesis tool for the mixed-coding-based MUXes (LaMUXes) is presented. Experimental results demonstrate that the LaMUX is exceptionally efficient, substantially reducing the usage of pneumatic controllers and microvalves compared to existing MUX designs. 

Characterizing low-energy, keV-range nuclear recoils near the detector threshold is one of the major challenges for large direct dark matter detectors. To that end, we have successfully used an Yttrium-Beryllium photoneutron source that emits 152 keV neutrons for the calibration of the light and charge yields of the XENONnT experiment for the first time. After data selection, we accumulated 474 events from 183 hours of exposure with this source. The expected background was $55\pm 12$accidental coincidence events, estimated using a dedicated 152 hour background calibration run with a Yttrium-PVC gamma-only source and data-driven modeling. From these calibrations, we extracted the light (charge) yield for liquid xenon at our field strength of $23\mathrm{V}/\mathrm{cm}$between 0.3 (0.7) ${\mathrm{keV}}_{\mathrm{NR}}$and $5.0{\mathrm{keV}}_{\mathrm{NR}}$. This calibration is crucial for accurately measuring the solar ${}^8\mathrm{B}$neutrino coherent elastic neutrino-nucleus scattering and searching for light dark matter particles with masses below $12\mathrm{GeV}/{\mathrm{c}}^2$. 

Integral digitalization aims to liaise with Universal interface for human-computer interaction, assemble Brewing aggregation via online analytical processing, and engage Centered user experience (UBC), which enables wiseCIO to orchestrate “Anything-as-a-Service” (XaaS). This paper presents three important concepts such as iDATA, iDEA and ACTiVE that together orchestrate XaaS on wiseCIO. iDATA stands for “integral digitalization via archival transformation and analytics” in support of content management, iDEA denotes “intelligence-driven efficient automation” for UBC processing with little coding required via machine learning automata, and ACTiVE represents “accessible, contextual and traceable information for vast engagement” with content delivery. Where iDATA is central to XaaS through computational thinking applied to multidimensional online analytical processing (mOLAP). Case studies are through discussed on the massive basis through iDATA over broad fields, such as manageable ARM (archival repository for manageable accessibility), animated BUS (biological understanding from STEM), sensible DASH (deliveries assembled for fast search & hits), smart DIGIA (digital intelligence governing instruction and administering), informative HARP (historical archives & religious preachings), vivid MATH (mathematical apps in teaching and hands-on exercise), and engaging SHARE (studies via hands-on assignment, review/revision and evaluation). As a result, iDATA-orchestrated wiseCIO is in favor of archival content management (ACM) and massive content delivery (MCD). Most recently, the comprehensive online teaching and learning (COTL) has been prepared and published as ACTiVE courseware with various multimedia and the student online profiles for paperless homework, labs and submissions. The ACTiVE courseware is integrated with a capacity equivalent to 10,000 + traditional web pages and broadly used for advanced remote learning (ARL) in both synchronous model and asynchronous model with great ease. 

Abstract. As cloud-based web services get more and more capable, available, and powerful (CAP), data science and engineering is pulled toward the frontline because DATA means almost anything-as-a-service (XaaS) via Digital Archiving and Transformed Analytics. In general, a web service (via a website) serves customers with web documents in HTML, JSON, XML, and multimedia via interactive (request) and responsive (reply) ways for specific domain problem solving over the Internet. In particular, a web service is deeply involved with UI & UX (user interface and user experience) plus considerate regulations on QoS (Quality of Service) as well, which refers to both information synthesis and security, namely availability and reliability for providential web services. This paper, based on the novel wiseCIO as a Platform-as-a-Service (PaaS), presents digital archiving 3 and transformed analytics (DATA) via machine learning, one of the most practical aspects of artificial intelligence. Machine learning is the science of data analysis that automates analytical model building and online analytical processing (OLAP) that enables computers to act without being explicitly programmed through CTMP. Computational thinking combined with manageable processing is 4 thoroughly discussed and utilized for FAST solutions in a feasible, analytical, scalable and testable approach. DATA is central to information synthesis and analytics (ISA), and digitized archives plays a key role in transformed analytics on intelligence for business, education and entertainment (iBEE). Case studies as applicable examples are discussed over broad fields where archival digitization is required for analytical transformation via machine learning, such as scalable ARM (archival repository for manageable accessibility), visual BUS (biological understanding from STEM), schooling DIGIA (digital intelligence governing instruction and administering), viewable HARP (historical archives & religious preachings), vivid MATH (mathematical apps in teaching and hands-on exercise), and SHARE (studies via hands-on assignment, revision and evaluation). As a result, wiseCIO promotes DATA service by providing ubiquitous web services of analytical processing via universal interface and user-centric experience in favor of logical organization of web content and relational information groupings that are vital steps in the ability of an archivist or librarian to recommend and retrieve information for a researcher. More important, wiseCIO also plays a key role as a content management system and delivery platform with capacity of hosting 10,000+ traditional web pages with great ease. 

We report on the search for x-ray radiation as predicted from dynamical quantum collapse with low-energy electronic recoil data in the energy range of 1–140 keV from the first science run of the XENONnT dark matter detector. Spontaneous radiation is an unavoidable effect of dynamical collapse models, which were introduced as a possible solution to the long-standing measurement problem in quantum mechanics. The analysis utilizes a model that for the first time accounts for cancellation effects in the emitted spectrum, which arise in the x-ray range due to the opposing electron-proton charges in xenon atoms. New world-leading limits on the free parameters of the Markovian continuous spontaneous localization and Diósi-Penrose models are set, improving previous best constraints by two orders of magnitude and a factor of five, respectively. For the strength and correlation length of the continuous spontaneous localization model, values in the originally proposed parameter ranges are experimentally excluded for the first time.