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The utility of active proteases as biomarkers is often limited by overlapping substrate specificity. Here, this feature is leveraged to develop a quantitative pattern-recognition sensing system driven by the degradation patterns of peptide–peptoid hybrid substrates to classify proteases and estimate their concentration by multivariate data analysis.more » « less
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Austin, Mariah J. ; Schunk, Hattie ; Watkins, Carolyn ; Ling, Natalie ; Chauvin, Jeremy ; Morton, Logan ; Rosales, Adrianne M. ( , Biomacromolecules)