skip to main content

Search for: All records

Creators/Authors contains: "Liu, Ming"

Note: When clicking on a Digital Object Identifier (DOI) number, you will be taken to an external site maintained by the publisher. Some full text articles may not yet be available without a charge during the embargo (administrative interval).
What is a DOI Number?

Some links on this page may take you to non-federal websites. Their policies may differ from this site.

  1. Running with a consistent cadence (number of steps per minute) is important for runners to help reduce risk of injury, improve running form, and enhance overall bio-mechanical efficiency. We introduce CaNRun, a non-contact and acoustic-based system that uses sound captured from a mobile device placed on a treadmill to predict and report running cadence. CaNRun obviates the need for runners to utilize wearable devices or carry a mobile device on their body while running on a treadmill. CaNRun leverages a long short-term memory (LSTM) network to extract steps observed from the microphone to robustly estimate cadence. Through an 8-person study, we demonstrate that CaNRun achieves cadence detection accuracy without calibration for individual users, which is comparable to the accuracy of the Apple Watch despite being non-contact.
    Free, publicly-accessible full text available May 9, 2024
  2. Free, publicly-accessible full text available April 12, 2024
  3. Free, publicly-accessible full text available January 27, 2024
  4. The SNP-set analysis is a powerful tool for dissecting the genetics of complex human diseases. There are three fundamental genetic association approaches to SNR-set analysis: the marginal model fitting approach, the joint model fitting approach, and the decorrelation approach. A problem of primary interest is how these approaches compare with each other. To address this problem, we develop a theoretical platform to compare the signal-to-noise ratio (SNR) of these approaches under the generalized linear model. We elaborate on how causal genetic effects give rise to statistically detectable association signals, and show that when causal effects spread over blocks of strong linkage disequilibrium (LD), the SNR of the marginal model fitting is usually higher than that of the decorrelation approach, which in turn is higher than that of the unbiased joint model fitting approach. We also scrutinize dense effects and LDs by a bivariate model and extensive simulations using the 1000 Genome Project data. Last, we compare the statistical power of two generic types of SNP-set tests (summation-based and supremum-based) by simulations and an osteoporosis study using large data from UK Biobank. Our results help develop powerful tools for SNP-set analysis and understand the signal detection problem in the presence ofmore »colored noise.« less
    Free, publicly-accessible full text available January 1, 2024
  5. Free, publicly-accessible full text available December 27, 2023
  6. Combining SNP p -values from GWAS summary data is a promising strategy for detecting novel genetic factors. Existing statistical methods for the p -value-based SNP-set testing confront two challenges. First, the statistical power of different methods depends on unknown patterns of genetic effects that could drastically vary over different SNP sets. Second, they do not identify which SNPs primarily contribute to the global association of the whole set. We propose a new signal-adaptive analysis pipeline to address these challenges using the omnibus thresholding Fisher’s method (oTFisher). The oTFisher remains robustly powerful over various patterns of genetic effects. Its adaptive thresholding can be applied to estimate important SNPs contributing to the overall significance of the given SNP set. We develop efficient calculation algorithms to control the type I error rate, which accounts for the linkage disequilibrium among SNPs. Extensive simulations show that the oTFisher has robustly high power and provides a higher balanced accuracy in screening SNPs than the traditional Bonferroni and FDR procedures. We applied the oTFisher to study the genetic association of genes and haplotype blocks of the bone density-related traits using the summary data of the Genetic Factors for Osteoporosis Consortium. The oTFisher identified more novel and literature-reportedmore »genetic factors than existing p -value combination methods. Relevant computation has been implemented into the R package TFisher to support similar data analysis.« less
    Free, publicly-accessible full text available November 17, 2023
  7. Free, publicly-accessible full text available October 23, 2023
  8. Free, publicly-accessible full text available November 22, 2023
  9. Free, publicly-accessible full text available October 1, 2023
  10. Free, publicly-accessible full text available October 1, 2023