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We present a hybrid optical-electrical analog deep learning (DL) accelerator, the first work to use incoherent optical signals for DL workloads. Incoherent optical designs are more attractive than coherent ones as the former can be more easily realized in practice. However, a significant challenge in analog DL accelerators, where multiply-accumulate operations are dominant, is that there is no known solution to perform accumulation using incoherent optical signals. We overcome this challenge by devising a hybrid approach: accumulation is done in the electrical domain, while multiplication is performed in the optical domain. The key technology enabler of our design is the transistor laser, which performs electrical-to-optical and optical-to-electrical conversions efficiently to tightly integrate electrical and optical devices into compact circuits. As such, our design fully realizes the ultra high-speed and high-energy-efficiency advantages of analog and optical computing. Our evaluation results using the MNIST benchmark show that our design achieves 2214× and 65× improvements in latency and energy, respectively, compared to a state-of-the-art memristor-based analog design. 

Tissue biopsy evaluation in the clinic is in need of quantitative disease markers for diagnosis and, most importantly, prognosis. Among the new technologies, quantitative phase imaging (QPI) has demonstrated promise for histopathology because it reveals intrinsic tissue nanoarchitecture through the refractive index. However, a vast majority of past QPI investigations have relied on imaging unstained tissues, which disrupts the established specimen processing. Here we present color spatial light interference microscopy (cSLIM) as a new whole-slide imaging modality that performs interferometric imaging on stained tissue, with a color detector array. As a result, cSLIM yields in a single scan both the intrinsic tissue phase map and the standard color bright-field image, familiar to the pathologist. Our results on 196 breast cancer patients indicate that cSLIM can provide stain-independent prognostic information from the alignment of collagen fibers in the tumor microenvironment. The effects of staining on the tissue phase maps were corrected by a mathematical normalization. These characteristics are likely to reduce barriers to clinical translation for the new cSLIM technology.