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Degradable ZnS-Supported Bioorthogonal Nanozymes with Enhanced Catalytic Activity for Intracellular Activation of Therapeutics

https://doi.org/10.1021/jacs.2c04571

Zhang, Xianzhi; Lin, Shichao; Huang, Rui; Gupta, Aarohi; Fedeli, Stefano; Cao-Milán, Roberto; Luther, David C; Liu, Yuanchang; Jiang, Mingdi; Li, Gengtan; et al (July 2022, Journal of the American Chemical Society)

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Cytosolic Delivery of Functional Proteins In Vitro through Tunable Gigahertz Acoustics

https://doi.org/10.1021/acsami.9b21131

Pan, Shuting; Jeon, Taewon; Luther, David C.; Duan, Xuexin; Rotello, Vincent M. (April 2020, ACS Applied Materials & Interfaces)

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Direct Cytosolic Delivery of Proteins through Coengineering of Proteins and Polymeric Delivery Vehicles

https://doi.org/10.1021/jacs.9b12759

Lee, Yi-Wei; Luther, David C.; Goswami, Ritabrita; Jeon, Taewon; Clark, Vincent; Elia, James; Gopalakrishnan, Sanjana; Rotello, Vincent M. (March 2020, Journal of the American Chemical Society)

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Thermally Gated Bio-orthogonal Nanozymes with Supramolecularly Confined Porphyrin Catalysts for Antimicrobial Uses

https://doi.org/10.1016/j.chempr.2020.01.015

Cao-Milán, Roberto; Gopalakrishnan, Sanjana; He, Luke D.; Huang, Rui; Wang, Li-Sheng; Castellanos, Laura; Luther, David C.; Landis, Ryan F.; Makabenta, Jessa Marie; Li, Cheng-Hsuan; et al (May 2020, Chem)

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Macrophage-Encapsulated Bioorthogonal Nanozymes for Targeting Cancer Cells

https://doi.org/10.1021/jacsau.2c00247

Das, Riddha; Hardie, Joseph; Joshi, Bishnu P.; Zhang, Xianzhi; Gupta, Aarohi; Luther, David C.; Fedeli, Stefano; Farkas, Michelle E.; Rotello, Vincent M. (July 2022, JACS Au)
In Vivo Editing of Macrophages through Systemic Delivery of CRISPR‐Cas9‐Ribonucleoprotein‐Nanoparticle Nanoassemblies

https://doi.org/10.1002/adtp.201900041

Lee, Yi‐Wei; Mout, Rubul; Luther, David C.; Liu, Yuanchang; Castellanos‐García, Laura; Burnside, Amy S.; Ray, Moumita; Tonga, Gulen Yeşilbag; Hardie, Joseph; Nagaraj, Harini; et al (August 2019, Advanced Therapeutics)

Abstract Macrophages are key effectors of host defense and metabolism, making them promising targets for transient genetic therapy. Gene editing through the delivery of Cas9‐ribonucleoprotein (RNP) provides multiple advantages over gene delivery–based strategies for introducing CRISPR machinery to the cell. There are, however, significant physiological, cellular, and intracellular barriers to the effective delivery of the Cas9 protein and guide RNA (sgRNA) that have to date, restricted in vivo Cas9 protein–based approaches to local/topical delivery applications. Described herein is a new nanoassembled platform featuring coengineered nanoparticles and Cas9 protein that has been developed to provide efficient Cas9‐sgRNA delivery and concomitant CRISPR editing through systemic tail‐vein injection into mice, achieving >8% gene editing efficiency in macrophages of the liver and spleen.
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