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Utilizing a microfluidic chip with serpentine channels, we inoculated the chip with an agar plug with Neurospora crassa mycelium and successfully captured individual hyphae in channels. For the first time, we report the presence of an autonomous clock in hyphae. Fluorescence of a mCherry reporter gene driven by a clock-controlled gene-2 promoter (ccg-2p) was measured simultaneously along hyphae every half an hour for at least 6 days. We entrained single hyphae to light over a wide range of day lengths, including 6,12, 24, and 36 h days. Hyphae tracked in individual serpentine channels were highly synchronized (K = 0.60-0.78). Furthermore, hyphae also displayed temperature compensation properties, where the oscillation period was stable over a physiological range of temperatures from 24 °C to 30 °C (Q10 = 1.00-1.10). A Clock Tube Model developed could mimic hyphal growth observed in the serpentine chip and provides a mechanism for the stable banding patterns seen in race tubes at the macroscopic scale and synchronization through molecules riding the growth wave in the device. 

Human visual grouping processes consolidate independent visual objects into grouped visual features on the basis of shared characteristics; these visual features can themselves be grouped, resulting in a hierarchical representation of visual grouping information. This “grouping hierarchy“ promotes ef- ficient attention in the support of goal-directed behavior, but improper grouping of elements of a visual scene can also re- sult in critical behavioral errors. Understanding of how visual object/features characteristics such as size and form influences perception of hierarchical visual groups can further theory of human visual grouping behavior and contribute to effective in- terface design. In the present study, participants provided free- response groupings of a set of stimuli that contained consistent structural relationships between a limited set of visual features. These grouping patterns were evaluated for relationships be- tween specific characteristics of the constituent visual features and the distribution of features across levels of the indicated grouping hierarchy. We observed that while the relative size of the visual features differentiated groupings across levels of the grouping hierarchy, the form of visual objects and features was more likely to distinguish separate groups within a partic- ular level of hierarchy. These consistent relationships between visual feature characteristics and placement within a grouping hierarchy can be leveraged to advance computational theories of human visual grouping behavior, which can in turn be ap- plied to effective design for interfaces such as voter ballots. 

Human visual grouping processes consolidate independent visual objects into grouped visual features on the basis of shared characteristics; these visual features can themselves be grouped, resulting in a hierarchical representation of visual grouping information. This “grouping hierarchy“ promotes ef- ficient attention in the support of goal-directed behavior, but improper grouping of elements of a visual scene can also re- sult in critical behavioral errors. Understanding of how visual object/features characteristics such as size and form influences perception of hierarchical visual groups can further theory of human visual grouping behavior and contribute to effective in- terface design. In the present study, participants provided free- response groupings of a set of stimuli that contained consistent structural relationships between a limited set of visual features. These grouping patterns were evaluated for relationships be- tween specific characteristics of the constituent visual features and the distribution of features across levels of the indicated grouping hierarchy. We observed that while the relative size of the visual features differentiated groupings across levels of the grouping hierarchy, the form of visual objects and features was more likely to distinguish separate groups within a partic- ular level of hierarchy. These consistent relationships between visual feature characteristics and placement within a grouping hierarchy can be leveraged to advance computational theories of human visual grouping behavior, which can in turn be ap- plied to effective design for interfaces such as voter ballots. 

The use of a microwell microfluidic device allows separating single cells and tracking single cells data. The measurement of single cell fluorescent intensity trajectories in the microwell device supported a deterministic quorum sensing model identified by ensemble methods for clock phase synchronization. A strong inference framework was used to test the communication mechanism in phase synchronization of quorum sensing versus cell-to-cell contact, and the results lent support for quorum sensing. 

Four inter-related measures of phase are described to study the phase synchronization of cellular oscillators, and computation of these measures is described and illustrated on single cell fluorescence data from the model filamentous fungus, Neurospora crassa. One of these four measures is the phase shift ϕ in a sinusoid of the form x(t) = A(cos(ωt + ϕ), where t is time. The other measures arise by creating a replica of the periodic process x(t) called the Hilbert transform x̃(t), which is 90 degrees out of phase with the original process x(t). The second phase measure is the phase angle FH(t) between the replica x̃(t) and X(t), taking values between -π and π. At extreme values the Hilbert Phase is discontinuous, and a continuous form FC(t) of the Hilbert Phase is used, measuring time on the nonnegative real axis (t). The continuous Hilbert Phase FC(t) is used to define the phase MC(t1,t0) for an experiment beginning at time t0 and ending at time t1. In that phase differences at time t0 are often of ancillary interest, the Hilbert Phase FC(t0) is subtracted from FC(t1). This difference is divided by 2π to obtain the phase MC(t1,t0) in cycles. Both the Hilbert Phase FC(t) and the phase MC(t1,t0) are functions of time and useful in studying when oscillators phase-synchronize in time in signal processing and circadian rhythms in particular. The phase of cellular clocks is fundamentally different from circadian clocks at the macroscopic scale because there is an hourly cycle superimposed on the circadian cycle. 

A search for the nonresonant production of Higgs boson pairs in the$HH\to b\overline{b}{\tau }^{+}{\tau }^{-}$channel is performed using$140{\mathrm{fb}}^{-1}$of proton-proton collisions at a center-of-mass energy of 13 TeV recorded by the ATLAS detector at the CERN Large Hadron Collider. The analysis strategy is optimized to probe anomalous values of the Higgs boson self-coupling modifier${\kappa }_{\lambda }$and of the quartic$HHVV$($V=W,Z$) coupling modifier${\kappa }_{2V}$. No significant excess above the expected background from Standard Model processes is observed. An observed (expected) upper limit${\mu }_{HH}<5.9(3.3)$is set at 95% confidence-level on the Higgs boson pair production cross section normalized to its Standard Model prediction. The coupling modifiers are constrained to an observed (expected) 95% confidence interval of$-3.1<{\kappa }_{\lambda }<9.0$($-2.5<{\kappa }_{\lambda }<9.3$) and$-0.5<{\kappa }_{2V}<2.7$($-0.2<{\kappa }_{2V}<2.4$), assuming all other Higgs boson couplings are fixed to the Standard Model prediction. The results are also interpreted in the context of effective field theories via constraints on anomalous Higgs boson couplings and Higgs boson pair production cross sections assuming different kinematic benchmark scenarios.

© 2024 CERN, for the ATLAS Collaboration2024CERN 

The ATLAS trigger system is a crucial component of the ATLAS experiment at the LHC. It is responsible for selecting events in line with the ATLAS physics programme. This paper presents an overview of the changes to the trigger and data acquisition system during the second long shutdown of the LHC, and shows the performance of the trigger system and its components in the proton-proton collisions during the 2022 commissioning period as well as its expected performance in proton-proton and heavy-ion collisions for the remainder of the third LHC data-taking period (2022–2025).

 

This paper presents a search for pair production of higgsinos, the supersymmetric partners of the Higgs bosons, in scenarios with gauge-mediated supersymmetry breaking. Each higgsino is assumed to decay into a Higgs boson and a nearly massless gravitino. The search targets events where each Higgs boson decays into$b\overline{b}$, leading to a reconstructed final state with at least three energetic$b$-jets and missing transverse momentum. Two complementary analysis channels are used, with each channel specifically targeting either low or high values of the higgsino mass. The low-mass (high-mass) channel exploits$126(139){\mathrm{fb}}^{-1}$of$\sqrt{s}=13\mathrm{TeV}$data collected by the ATLAS detector during Run 2 of the Large Hadron Collider. No significant excess above the Standard Model prediction is found. At 95% confidence level, masses between 130 GeV and 940 GeV are excluded for higgsinos decaying exclusively into Higgs bosons and gravitinos. Exclusion limits as a function of the higgsino decay branching ratio to a Higgs boson are also reported.

© 2024 CERN, for the ATLAS Collaboration2024CERN 

A combination of fifteen top quark mass measurements performed by the ATLAS and CMS experiments at the LHC is presented. The datasets used correspond to an integrated luminosity of up to 5 and$20{\mathrm{fb}}^{-1}$of proton-proton collisions at center-of-mass energies of 7 and 8 TeV, respectively. The combination includes measurements in top quark pair events that exploit both the semileptonic and hadronic decays of the top quark, and a measurement using events enriched in single top quark production via the electroweak$t$channel. The combination accounts for the correlations between measurements and achieves an improvement in the total uncertainty of 31% relative to the most precise input measurement. The result is$m_t=172.52\pm 0.14(\mathrm{stat})\pm 0.30(\mathrm{syst})\mathrm{GeV}$, with a total uncertainty of 0.33 GeV.