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null (Ed.)Abstract This paper presents research results of biocidal effect of thermoplastic- polyester-elastomer (TPE-E) with incorporation of hybrid Ag/ZnO/SiO 2 NPs (silver/Zinc oxide/SiO 2 nanoparticles). These results were compared with various gamma-irradiated doses and processing techniques including extrusion, injection molding and compression molding. In all these processing techniques the TPE-E was mixed with mineral oil and Ag/ZnO/SiO 2 nanoparticles. The TPE-E nanocomposites were characterized by differential scanning calorimetry (DSC), thermogravimetry analysis (TGA), Infrared FT spectroscopy (FTIR), surface enhanced Raman technique ( SERS), FESEM (Field emission scanning electron microscopy), Energy-dispersive X-ray spectroscopy (EDS), X-ray diffraction (XRD), TEM (transmission electronic microscopy) and antimicrobial test. Antibacterial activity against E. coli and S. aureus , are reported and these results showed potential application in health care products.more » « less