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Recent advances (2019–2021) of capillary electrophoresis‐mass spectrometry for multilevel proteomicsChen, Daoyang ; McCool, Elijah N. ; Yang, Zhichang ; Shen, Xiaojing ; Lubeckyj, Rachele A. ; Xu, Tian ; Wang, Qianjie ; Sun, Liangliang ( , Mass Spectrometry Reviews)Multilevel proteomics aims to delineate proteins at the peptide (bottom-up proteomics), proteoform (top-down proteomics), and protein complex (native proteomics) levels. Capillary electrophoresis-mass spectrometry (CE-MS) can achieve highly efficient separation and highly sensitive detection of complex mixtures of peptides, proteoforms, and even protein complexes because of its substantial technical progress. CE-MS has become a valuable alternative to the routinely used liquid chromatography-mass spectrometry for multilevel proteomics. This review summarizes the most recent (2019-2021) advances of CE-MS for multilevel proteomics regarding technological progress and biological applications. We also provide brief perspectives on CE-MS for multilevel proteomics at the end, highlighting some future directions and potential challenges.more » « less
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Xu, Tian ; Shen, Xiaojing ; Yang, Zhichang ; Chen, Daoyang ; Lubeckyj, Rachele A. ; McCool, Elijah N. ; Sun, Liangliang ( , Analytical Chemistry)null (Ed.)
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Chen, Daoyang ; Lubeckyj, Rachele A. ; Yang, Zhichang ; McCool, Elijah N. ; Shen, Xiaojing ; Wang, Qianjie ; Xu, Tian ; Sun, Liangliang ( , Analytical Chemistry)
