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Recurrence and drug resistance are major challenges in the treatment of acute myeloid leukemia (AML) that spur efforts to identify new clinical targets and active agents. STAT3 has emerged as a potential target in resistant AML, but inhibiting STAT3 function has proven challenging. This paper describes synthetic studies and biological assays for a naphthalene sulfonamide inhibitor class of molecules that inhibit G-CSF-induced STAT3 phosphorylation in cellulo and induce apoptosis in AML cells. We describe two different approaches to inhibitor design: first, variation of substituents on the naphthalene sulfonamide core allows improvements in anti-STAT activity and creates a more thorough understanding of anti-STAT SAR. Second, a novel approach involving hybrid sulfonamide–rhodium( ii ) conjugates tests our ability to use cooperative organic–inorganic binding for drug development, and to use SAR studies to inform metal conjugate design. Both approaches have produced compounds with improved binding potency. In vivo and in cellulo experiments further demonstrate that these approaches can also lead to improved activity in living cells, and that compound 3aa slows disease progression in a xenograft model of AML. 

Exploring the effects of solar eclipses on radio wave propagation has been an active area of research since the first experiments conducted in 1912. In the first few decades of ionospheric physics, researchers started to explore the natural laboratory of the upper atmosphere. Solar eclipses offered a rare opportunity to undertake an active experiment. The results stimulated much scientific discussion. Early users of radio noticed that propagation was different during night and day. A solar eclipse provided the opportunity to study this day/night effect with much sharper boundaries than at sunrise and sunset, when gradual changes occur along with temperature changes in the atmosphere and variations in the sun angle. Plots of amplitude time series were hypothesized to indicate the recombination rates and reionization rates of the ionosphere during and after the eclipse, though not all time-amplitude plots showed the same curve shapes. A few studies used multiple receivers paired with one transmitter for one eclipse, with a 5:1 ratio as the upper bound. In these cases, the signal amplitude plots generated for data received from the five receive sites for one transmitter varied greatly in shape. Examination of very earliest results shows the difficulty in using a solar eclipse to study propagation; different researchers used different frequencies from different locations at different times. Solar eclipses have been used to study propagation at a range of radio frequencies. For example, the first study in 1912 used a receiver tuned to 5,500 meters, roughly 54.545 kHz. We now have data from solar eclipses at frequencies ranging from VLF through HF, from many different sites with many different eclipse effects. This data has greatly contributed to our understanding of the ionosphere. The solar eclipse over the United States on August 21, 2017 presents an opportunity to have many locations receiving from the same transmitters. Experiments will target VLF, LF, and HF using VLF/LF transmitters, NIST’s WWVB time station at 60 kHz, and hams using their HF frequency allocations. This effort involves Citizen Science, wideband software defined radios, and the use of the Reverse Beacon Network and WSPRnet to collect eclipse-related data. 

Exploring the effects of solar eclipses on radio wave propagation has been an active area of research since the first experiments conducted in 1912. In the first few decades of ionospheric physics, researchers started to explore the natural laboratory of the upper atmosphere. Solar eclipses offered a rare opportunity to undertake an active experiment. The results stimulated much scientific discussion. Early users of radio noticed that propagation was different during night and day. A solar eclipse provided the opportunity to study this day/night effect with much sharper boundaries than at sunrise and sunset, when gradual changes occur along with temperature changes in the atmosphere and variations in the sun angle. Plots of amplitude time series were hypothesized to indicate the recombination rates and reionization rates of the ionosphere during and after the eclipse, though not all time-amplitude plots showed the same curve shapes. A few studies used multiple receivers paired with one transmitter for one eclipse, with a 5:1 ratio as the upper bound. In these cases, the signal amplitude plots generated for data received from the five receive sites for one transmitter varied greatly in shape. Examination of very earliest results shows the difficulty in using a solar eclipse to study propagation; different researchers used different frequencies from different locations at different times. Solar eclipses have been used to study propagation at a range of radio frequencies. For example, the first study in 1912 used a receiver tuned to 5,500 meters, roughly 54.545 kHz. We now have data from solar eclipses at frequencies ranging from VLF through HF, from many different sites with many different eclipse effects. This data has greatly contributed to our understanding of the ionosphere. The solar eclipse over the United States on August 21, 2017 presents an opportunity to have many locations receiving from the same transmitters. Experiments will target VLF, LF, and HF using VLF/LF transmitters, NIST?s WWVB time station at 60 kHz, and hams using their HF frequency allocations. This effort involves Citizen Science, wideband software defined radios, and the use of the Reverse Beacon Network and WSPRnet to collect eclipse-related data. 

The total solar eclipse over the continental United States on 21 August 2017 offered a unique opportunity to study the dependence of the ionospheric density and morphology on incident solar radiation at different local times. The Super Dual Auroral Radar Network (SuperDARN) radars in Christmas Valley, Oregon, and Fort Hays, Kansas, are located slightly southward of the line of totality; they both made measurements of the eclipsed ionosphere. The received power of backscattered signal decreases during the eclipse, and the slant ranges from the westward looking radar beams initially increase and then decrease after totality. The time scales over which these changes occur at each site differ significantly from one another. For Christmas Valley the propagation changes are fairly symmetric in time, with the largest slant ranges and smallest power return occurring coincident with the closest approach of totality to the radar. The Fort Hays signature is less symmetric. In order to investigate the underlying processes governing the ionospheric eclipse response, we use a ray‐tracing code to simulate SuperDARN data in conjunction with different eclipsed ionosphere models. In particular, we quantify the effect of the neutral wind velocity on the simulated data by testing the effect of adding/removing various neutral wind vector components. The results indicate that variations in meridional winds have a greater impact on the modeled ionospheric eclipse response than do variations in zonal winds. The geomagnetic field geometry and the line‐of‐sight angle from each site to the Sun appear to be important factors that influence the ionospheric eclipse response.