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Agriculture will play a central role in meeting greenhouse gas (GHG) emission targets, as the sector currently contributes ∼22% of global emissions. Because emissions are directly tied to resources employed in farm production, such as land, fertilizer, and ruminant animals, the productivity of input use tends to be inversely related to emissions intensity. We review evidence on how productivity gains in agriculture have contributed to historical changes in emissions, how they affect land use emissions both locally and globally, and how investments in research and development (R&D) affect productivity and therefore emissions. The world average agricultural emissions intensity fell by more than half since 1990, with a strong correlation between a region's agricultural productivity growth and reduction in emissions intensity. Additional investment in agricultural R&D offers an opportunity for cost-effective ( 

Disruption is a serious and common problem for the airline industry. High utilisation of aircraft and airport resources mean that disruptive events can have large knock-on effects for the rest of the schedule. The airline must rearrange their schedule to reduce the impact. The focus in this paper is on the Aircraft Recovery Problem. The complexity and uncertainty involved in the industry makes this a difficult problem to solve. Many deterministic modelling approaches have been proposed, but these struggle to handle the inherent variability in the problem. This paper proposes a multi-fidelity modelling framework, enabling uncertain elements of the environment to be included within the decision making process. We combine a deterministic integer program to find initial solutions and a novel simulation optimisation procedure to improve these solutions. This allows the solutions to be evaluated whilst accounting for the uncertainty of the problem. The empirical evaluation suggests that the combination consistently finds good rescheduling options. 

The nonstationary Poisson process (NSPP) is a workhorse tool for modeling and simulating arrival processes with time-dependent rates. In many applications only a single sequence of arrival times are observed. While one sample path is sufficient for estimating the arrival rate or integrated rate function of the process—as we illustrate in this paper—we show that testing for Poissonness, in the general case, is futile. In other words, when only a single sequence of arrival data are observed then one can fit an NSPP to it, but the choice of “NSPP” can only be justified by an understanding of the underlying process physics, or a leap of faith, not by testing the data. This result suggests the need for sensitivity analysis when such a model is used to generate arrivals in a simulation. 

Cheap parallel computing has greatly extended the reach of ranking & selection (R&S) for simulation optimization. In this paper we present an evaluation of bi-PASS, a R&S procedure created specifically for parallel implementation and very large numbers of system designs. We compare bi-PASS to the state-ofthe- art Good Selection Procedure and an easy-to-implement subset selection procedure. This is one of the few papers to consider both computational and statistical comparison of parallel R&S procedures. 

Computational thinking (CT) is ubiquitous in modern science, yet rarely integrated at the elementary school level. Moreover, access to computer science education at the PK-12 level is inequitably distributed. We believe that access to CT must be available earlier and implemented with the support of an equitable pedagogical framework. Our poster will describe our Accessible Computational Thinking (ACT) research project exploring professional development with elementary teachers on integrating computational thinking with Culturally Responsive Teaching practices. 

Computational thinking (CT) is ubiquitous in modern science, yet rarely integrated at the elementary school level. Moreover, access to computer science education at the PK-12 level is inequitably distributed. We believe that access to CT must be available earlier and implemented with the support of an equitable pedagogical framework. Our poster will describe our Accessible Computational Thinking (ACT) research project exploring professional development with elementary teachers on integrating computational thinking with Culturally Responsive Teaching practices. 

Potassium ion (K + ) plays a critical role as an essential electrolyte in all biological systems. Genetically-encoded fluorescent K + biosensors are promising tools to further improve our understanding of K + -dependent processes under normal and pathological conditions. Here, we report the crystal structure of a previously reported genetically-encoded fluorescent K + biosensor, GINKO1, in the K + -bound state. Using structure-guided optimization and directed evolution, we have engineered an improved K + biosensor, designated GINKO2, with higher sensitivity and specificity. We have demonstrated the utility of GINKO2 for in vivo detection and imaging of K + dynamics in multiple model organisms, including bacteria, plants, and mice. 

Abstract Tourette syndrome (TS) is a neuropsychiatric disorder of complex genetic architecture involving multiple interacting genes. Here, we sought to elucidate the pathways that underlie the neurobiology of the disorder through genome-wide analysis. We analyzed genome-wide genotypic data of 3581 individuals with TS and 7682 ancestry-matched controls and investigated associations of TS with sets of genes that are expressed in particular cell types and operate in specific neuronal and glial functions. We employed a self-contained, set-based association method (SBA) as well as a competitive gene set method (MAGMA) using individual-level genotype data to perform a comprehensive investigation of the biological background of TS. Our SBA analysis identified three significant gene sets after Bonferroni correction, implicating ligand-gated ion channel signaling, lymphocytic, and cell adhesion and transsynaptic signaling processes. MAGMA analysis further supported the involvement of the cell adhesion and trans-synaptic signaling gene set. The lymphocytic gene set was driven by variants in FLT3 , raising an intriguing hypothesis for the involvement of a neuroinflammatory element in TS pathogenesis. The indications of involvement of ligand-gated ion channel signaling reinforce the role of GABA in TS, while the association of cell adhesion and trans-synaptic signaling gene set provides additional support for the role of adhesion molecules in neuropsychiatric disorders. This study reinforces previous findings but also provides new insights into the neurobiology of TS.