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Saleem, M. (Ed.)NKX3.1’s downregulation is strongly associated with prostate cancer (PCa) initiation, progression, and CRPC development. Nevertheless, a clear disagreement exists between NKX3.1 protein and mRNA levels in PCa tissues, indicating that its regulation at a post-translational level plays a vital role. This study identified a strong negative relationship between NKX3.1 and LIMK2, which is critical in CRPC pathogenesis. We identified that NKX3.1 degradation by direct phosphorylation by LIMK2 is crucial for promoting oncogenicity in CRPC cells and in vivo. LIMK2 also downregulates NKX3.1 mRNA levels. In return, NKX3.1 promotes LIMK2’s ubiquitylation. Thus, the negative crosstalk between LIMK2-NKX3.1 regulates AR, ARv7, andmore »
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In recent years, the need to exploit digitized document data has been increasing. In this paper, we address the problem of parsing digitized Vietnamese paper documents. The digitized Vietnamese documents are mainly in the form of scanned images with diverse layouts and special characters introducing many challenges. To this end, we first collect the UIT-DODV dataset, a novel Vietnamese document image dataset that includes scientific papers in Vietnamese derived from different scientific conferences. We compile both images that were converted from PDF and scanned by a smartphone in addition a physical scanner that poses many new challenges. Additionally, we furthermore »
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This paper evaluates the performances of dry, minimum quantity lubrication (MQL), and MQL with nanofluid conditions in turning of the most common titanium (Ti) alloy, Ti-6Al-4 V, in a solution treated and aged (STA) microstructure. In particular, the nanofluid evaluated here is vegetable (rapeseed) oil mixed with small concentrations of exfoliated graphite nanoplatelets (xGnPs). This paper focuses on turning process that imposes a challenging condition to apply the oil or nanofluid droplets directly onto the tribological surfaces of a cutting tool due to the uninterrupted engagement between tool and work material during cutting. A series of turning experiments was conductedmore »
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Introduction: Spheroids show great promise in being a better model for testing treatments for cancer in vitro when compared to monolayer cells. Single photon imaging of spheroids is limited by depth. Due to this reason, two photon imaging is necessary to obtain a full image of the spheroid. We developed a software that can evaluate the cellular metabolism of a spheroid by calculating the Redox Index (NADH divided by FAD). We tried to validate this software by treating the spheroids with an ATP antagonist.
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Free, publicly-accessible full text available March 1, 2023
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Titanium alloys typically do not contain hard inclusion phases typically observed in other metallic alloys. However, the characteristic scoring marks and more distinctive micro- and/or macro-chippings are ubiquitously observed on the flank faces of cutting tools in machining titanium alloys, which is the direct evidence of abrasive wear (hard phase(s) in the microstructure abrading and damaging the flank surface). Thus, an important question lies with the nature of the hard phases present in the titanium microstructure. In this work, we present a comprehensive study that examines the microstructural impact on flank wear attained by turning various Ti-6Al-4V bars having distinctmore »
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Free, publicly-accessible full text available October 1, 2022
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Quasielastic C12(e,e′p) scattering was measured at spacelike 4-momentum transfer squared Q2=8, 9.4, 11.4, and 14.2 (GeV/c)2, the highest ever achieved to date. Nuclear transparency for this reaction was extracted by comparing the measured yield to that expected from a plane-wave impulse approximation calculation without any final state interactions. The measured transparency was consistent with no Q2 dependence, up to proton momenta of 8.5 GeV/c, ruling out the quantum chromodynamics effect of color transparency at the measured Q2 scales in exclusive (e,e′p) reactions. These results impose strict constraints on models of color transparency for protons.