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Creators/Authors contains: "O’Doherty, George A."

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  1. ; ; ; (, Chemical Communications)
    The development and application of the asymmetric synthesis of oligosaccharides from achiral starting materials is reviewed. This de novo asymmetric approach centers around the use of asymmetric catalysis for the synthesis of optically pure furan alcohols in conjunction with Achmatowicz oxidative rearrangement for the synthesis of various pyranones. In addition, the use of a diastereoselective palladium-catalyzed glycosylation and subsequent diastereoselective post-glycosylation transformation was used for the synthesis of oligosaccharides. The application of this approach to oligosaccharide synthesis is discussed. 
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  2. ; (, The Journal of Organic Chemistry)
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  3. ; ; ; ; ; (, Molecules)
    A diastereoselective synthesis of the β-anomer of glycinamide ribonucleotide (β-GAR) has been developed. The synthesis was accomplished in nine steps from D-ribose and occurred in 5% overall yield. The route provided material on the multi-milligram scale. The synthetic β-GAR formed was remarkably resistant to anomerization both in solution and as a solid. 
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  4. ; ; ; ; ; (, Journal of CO2 Utilization)
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  5. ; ; ; ; ; (, Journal of Enzyme Inhibition and Medicinal Chemistry)
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  6. ; ; ; ; ; ; (, ACS Chemical Biology)