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Free, publicly-accessible full text available April 1, 2023
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Free, publicly-accessible full text available February 1, 2023
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Free, publicly-accessible full text available November 1, 2022
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OBJECTIVES: Prediction and determination of drug efficacy for radiographic progression is limited by the heterogeneity inherent in axial spondyloarthritis (axSpA). We investigated whether unbiased clustering analysis of phenotypic data can lead to coherent subgroups of axSpA patients with a distinct risk of radiographic progression. METHODS: A group of 412 patients with axSpA was clustered in an unbiased way using a agglomerative hierarchical clustering method, based on their phenotype mapping. We used a generalised linear model, naïve Bayes, Decision Trees, K-Nearest-Neighbors, and Support Vector Machines to construct a consensus classification method. Radiographic progression over 2 years was assessed using the modifiedmore »
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Abstract The anomalous diffusion of resonant protons in parallel and perpendicular velocity space by kinetic Alfvén waves is discussed. The velocity diffusion coefficient is calculated by employing an autocorrelation function for proton trajectories. It is found that for protons resonant with the waves, the perpendicular diffusion coefficient decays away for a sufficiently long time, but parallel diffusion monotonically increases in time until it saturates at a certain level. This result indicates that a portion of resonant protons can undergo anomalous diffusion along the background magnetic field even if the intensity of the kinetic Alfvén wave is sufficiently low. The presentmore »
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Free, publicly-accessible full text available February 1, 2023
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Abstract We present a background model for dark matter searches using an array of NaI(Tl) crystals in the COSINE-100 experiment that is located in the Yangyang underground laboratory. The model includes background contributions from both internal and external sources, including cosmogenic radionuclides and surface $$^{210}$$ 210 Pb contamination. To build the model in the low energy region, with a threshold of 1 keV, we used a depth profile of $$^{210}$$ 210 Pb contamination in the surface of the NaI(Tl) crystals determined in a comparison between measured and simulated spectra. We also considered the effect of the energy scale errors propagated frommore »Free, publicly-accessible full text available September 1, 2022