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Survival analysis is a crucial statistical technique used to estimate the anticipated duration until a specific event occurs. However, current methods often involve discretizing the time scale and struggle with managing absent features within the data. This becomes especially pertinent since events can transpire at any given point, rendering event analysis a continuous concern. Additionally, the presence of missing attributes within tabular data is widespread. By leveraging recent developments of Transformer and Self-Supervised Learning (SSL), we introduce SSL-SurvFormer. This entails a continuously monotonic Transformer network, empowered by SSL pre-training, that is designed to address the challenges presented by continuous events and absent features in survival prediction. Our proposed continuously monotonic Transformer model facilitates accurate estimation of survival probabilities, thereby bypassing the need for temporal discretization. Additionally, our SSL pre-training strategy incorporates data transformation to adeptly manage missing information. The SSL pre-training encompasses two tasks: mask prediction, which identifies positions of absent features, and reconstruction, which endeavors to recover absent elements based on observed ones. Our empirical evaluations conducted across a variety of datasets, including FLCHAIN, METABRIC, and SUPPORT, consistently highlight the superior performance of SSL-SurvFormer in comparison to existing methods. Additionally, SSL-SurvFormer demonstrates effectiveness in handling missing values, a critical aspect often encountered in real-world datasets. 

Abstract Patients with influenza and SARS-CoV2/Coronavirus disease 2019 (COVID-19) infections have a different clinical course and outcomes. We developed and validated a supervised machine learning pipeline to distinguish the two viral infections using the available vital signs and demographic dataset from the first hospital/emergency room encounters of 3883 patients who had confirmed diagnoses of influenza A/B, COVID-19 or negative laboratory test results. The models were able to achieve an area under the receiver operating characteristic curve (ROC AUC) of at least 97% using our multiclass classifier. The predictive models were externally validated on 15,697 encounters in 3125 patients available on TrinetX database that contains patient-level data from different healthcare organizations. The influenza vs COVID-19-positive model had an AUC of 98.8%, and 92.8% on the internal and external test sets, respectively. Our study illustrates the potentials of machine-learning models for accurately distinguishing the two viral infections. The code is made available athttps://github.com/ynaveena/COVID-19-vs-Influenzaand may have utility as a frontline diagnostic tool to aid healthcare workers in triaging patients once the two viral infections start cocirculating in the communities.