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Abstract We present 3 yr of high-contrast imaging of the PDS 70 b and c accreting protoplanets with the new extreme AO system MagAO-X as part of the MaxProtoPlanetS survey of Hαprotoplanets. In 2023 and 2024, our sharp (25–27 mas FWHM), well-AO-corrected (20%–26% Strehl), deep (2–3.6 hr) images detected compact (r∼ 30 mas;r∼ 3 au) circumplanetary disks (CPDs) surrounding both protoplanets. Starlight scattering off the front edge of these dusty CPDs is the likely source of the bright compact continuum light detected within ∼30 mas of both planets in our simultaneously obtained continuum 668 nm filter images. After subtraction of contaminating continuum and point-spread function residuals withpyKLIPangular differential imaging and spectral differential imaging, we obtained high-contrast ASDI Hαimages of both planets in 2022, 2023, and 2024. We find the Hαline flux of planet b fell by (8.1 ± 1.6) × 10⁻¹⁶erg s⁻¹cm⁻², a factor of 4.6 drop in flux from 2022 to 2023. In 2024 March, planet b continued to be faint with just a slight 1.6× rise to an Hαline flux of (3.64 ± 0.87) × 10⁻¹⁶erg s⁻¹cm⁻². For c, we measure a significant increase of (2.74 ± 0.51) × 10⁻¹⁶erg s⁻¹cm⁻²from 2023 to 2024, which is a factor of 2.3 increase. So both protoplanets have recently experienced significant Hαvariability with ∼1 yr sampling. In 2024, planet c is brighter than b: as c is brightening and b generally fading. We also tentatively detect one new point source “CC3” inside the inner disk (∼49 mas; at PA ∼ 295°; 2024) with orbital motion roughly consistent with a ∼5.6 au orbit. 

ABSTRACT We present 1.3 mm continuum ALMA long-baseline observations at 3–5 au resolution of 10 of the brightest discs from the Ophiuchus DIsc Survey Employing ALMA (ODISEA) project. We identify a total of 26 narrow rings and gaps distributed in 8 sources and 3 discs with small dust cavities (r <10 au). We find that two discs around embedded protostars lack the clear gaps and rings that are ubiquitous in more evolved sources with Class II SEDs. Our sample includes five objects with previously known large dust cavities (r >20 au). We find that the 1.3 mm radial profiles of these objects are in good agreement with those produced by numerical simulations of dust evolution and planet–disc interactions, which predict the accumulation of mm-sized grains at the edges of planet-induced cavities. Our long-baseline observations resulted in the largest sample of discs observed at ∼3–5 au resolution in any given star-forming region (15 objects when combined with Ophiuchus objects in the DSHARP Large Program) and allow for a demographic study of the brightest $$\sim\! 5{{\ \rm per\ cent}}$$ of the discs in Ophiuchus (i.e. the most likely formation sites of giant planets in the cloud). We use this unique sample to propose an evolutionary sequence and discuss a scenario in which the substructures observed in massive protoplanetary discs are mainly the result of planet formation and dust evolution. If this scenario is correct, the detailed study of disc substructures might provide a window to investigate a population of planets that remains mostly undetectable by other techniques. 

The highly infectious disease COVID-19 caused by the Betacoronavirus SARS-CoV-2 poses a severe threat to humanity and demands the redirection of scientific efforts and criteria to organized research projects. The international COVID19-NMR consortium seeks to provide such new approaches by gathering scientific expertise worldwide. In particular, making available viral proteins and RNAs will pave the way to understanding the SARS-CoV-2 molecular components in detail. The research in COVID19-NMR and the resources provided through the consortium are fully disclosed to accelerate access and exploitation. NMR investigations of the viral molecular components are designated to provide the essential basis for further work, including macromolecular interaction studies and high-throughput drug screening. Here, we present the extensive catalog of a holistic SARS-CoV-2 protein preparation approach based on the consortium’s collective efforts. We provide protocols for the large-scale production of more than 80% of all SARS-CoV-2 proteins or essential parts of them. Several of the proteins were produced in more than one laboratory, demonstrating the high interoperability between NMR groups worldwide. For the majority of proteins, we can produce isotope-labeled samples of HSQC-grade. Together with several NMR chemical shift assignments made publicly available on covid19-nmr.com , we here provide highly valuable resources for the production of SARS-CoV-2 proteins in isotope-labeled form.