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This paper proposes and develops a new Newton-type algorithm to solve subdifferential inclusions defined by subgradients of extended real-valued prox-regular functions. The proposed algorithm is formulated in terms of the second order subdifferential of such functions that enjoy extensive calculus rules and can be efficiently computed for broad classes of extended real-valued functions. Based on this and on the metric regularity and subregularity properties of subgradient mappings, we establish verifiable conditions ensuring the well-posedness of the proposed algorithm and its local superlinear convergence. The obtained results are also new for the class of equations defined by continuously differentiable functions with Lipschitzian gradients ([Formula: see text] functions), which is the underlying case of our consideration. The developed algorithms for prox-regular functions and their extension to a structured class of composite functions are formulated in terms of proximal mappings and forward–backward envelopes. Besides numerous illustrative examples and comparison with known algorithms for [Formula: see text] functions and generalized equations, the paper presents applications of the proposed algorithms to regularized least square problems arising in statistics, machine learning, and related disciplines. Funding: Research of P. D. Khanh is funded by Ho Chi Minh City University of Education Foundation for Science and Technology [Grant CS.2022.19.20TD]. Research of B. Mordukhovich and V. T. Phat was partly supported by the U.S. National Science Foundation [Grants DMS-1808978 and DMS-2204519]. The research of B. Mordukhovich was also supported by the Air Force Office of Scientific Research [Grant 15RT0462] and the Australian Research Council under Discovery Project DP-190100555. This work was supported by the Air Force Office of Scientific Research [Grant 15RT0462].