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Abstract The Virgo Filament Survey (VFS) is a comprehensive study of galaxies that reside in the extended filamentary structures surrounding the Virgo Cluster, out to 12 virial radii. The primary goal is to characterize all of the dominant baryonic components within galaxies and to understand whether and how they are affected by the filament environment. A key constituent of VFS is a narrowband Hαimaging survey of over 600 galaxies, VFS-Hα. The Hαimages reveal detailed, resolved maps of the ionized gas and massive star formation. This imaging is particularly powerful as a probe of environmentally induced quenching because different physical processes affect the spatial distribution of star formation in different ways. In this paper, we present the first results from the VFS-Hαfor the NGC 5364 group, a low-mass ( ${\log }_{10}(M_{\mathrm{dyn}}/M_{\odot })<13$) system located at the western edge of the Virgo III filament. We combine Hαimaging with resolved Hiobservations from MeerKAT for eight group members. These galaxies exhibit peculiar morphologies, including strong distortions in the stars and the gas, truncated Hiand Hαdisks, H itails, extraplanar Hαemission, and off-center Hαemission. These signatures are suggestive of environmental processing such as tidal interactions, ram pressure stripping, and starvation. We quantify the role of ram pressure stripping expected in this group, and find that it can explain the cases of Hitails and truncated Hαfor all but one of the disk-dominated galaxies. Our observations indicate that multiple physical mechanisms are disrupting the baryon cycle in these group galaxies. 

Fungi in the familyEntomophthoraceaeare prevalent pathogens of aphids. Facultative symbiotic bacteria harbored by aphids, includingSpiroplasma sp. andRegiella insecticola, have been shown to make their hosts more resistant to infection with the fungal pathogenPandora neoaphidis. How far this protection extends against other species of fungi in the familyEntomophthoraceaeis unknown. Here we isolated a strain of the fungal pathogenBatkoa apiculatainfecting a natural population of pea aphids (Acyrthosiphon pisum) and confirmed its identity by sequencing the 28S rRNA gene. We then infected a panel of aphids each harboring a different species or strain of endosymbiotic bacteria to test whether aphid symbionts protect againstB.apiculata. We found no evidence of symbiont-mediated protection against this pathogen, and our data suggest that some symbionts make aphids more susceptible to infection. This finding is relevant to our understanding of this important model of host-microbe interactions, and we discuss our results in the context of aphid-microbe ecological and evolutionary dynamics. 

Abstract The brain is composed of networks of interacting brain regions that support higher-order cognition. Among these, a core network of regions has been associated with recollection and other forms of episodic construction. Past research has focused largely on the roles of individual brain regions in recollection or on their mutual engagement as part of an integrated network. However, the relationship between these region- and network-level contributions remains poorly understood. Here, we applied multilevel structural equation modeling to examine the functional organization of the posterior medial (PM) network and its relationship to episodic memory outcomes. We evaluated two aspects of functional heterogeneity in the PM network: first, the organization of individual regions into subnetworks, and second, the presence of regionally specific contributions while accounting for network-level effects. Our results suggest that the PM network is composed of ventral and dorsal subnetworks, with the ventral subnetwork making a unique contribution to recollection, especially to recollection of spatial information, and that memory-related activity in individual regions is well accounted for by these network-level effects. These findings highlight the importance of considering the functions of individual brain regions within the context of their affiliated networks. 

ABSTRACT We investigate the role of dense environments in suppressing star formation by studying $$\rm \log _{10}(M_\star /M_\odot) \gt 9.7$$ star-forming galaxies in nine clusters from the Local Cluster Survey (0.0137 < z < 0.0433) and a large comparison field sample drawn from the Sloan Digital Sky Survey. We compare the star formation rate (SFR) with stellar mass relation as a function of environment and morphology. After carefully controlling for mass, we find that in all environments, the degree of SFR suppression increases with increasing bulge-to-total (B/T) ratio. In addition, the SFRs of cluster and infall galaxies at a fixed mass are more suppressed than their field counterparts at all values of B/T. These results suggest a quenching mechanism that is linked to bulge growth that operates in all environments and an additional mechanism that further reduces the SFRs of galaxies in dense environments. We limit the sample to B/T ≤ 0.3 galaxies to control for the trends with morphology and find that the excess population of cluster galaxies with suppressed SFRs persists. We model the time-scale associated with the decline of SFRs in dense environments and find that the observed SFRs of the cluster core galaxies are consistent with a range of models including a mechanism that acts slowly and continuously over a long (2–5 Gyr) time-scale, and a more rapid (<1 Gyr) quenching event that occurs after a delay period of 1–6 Gyr. Quenching may therefore start immediately after galaxies enter clusters. 

The field of plant science has grown dramatically in the past two decades, but global disparities and systemic inequalities persist. Here, we analyzed ~300,000 papers published over the past two decades to quantify disparities across nations, genders, and taxonomy in the plant science literature. Our analyses reveal striking geographical biases—affluent nations dominate the publishing landscape and vast areas of the globe have virtually no footprint in the literature. Authors in Northern America are cited nearly twice as many times as authors based in Sub-Saharan Africa and Latin America, despite publishing in journals with similar impact factors. Gender imbalances are similarly stark and show remarkably little improvement over time. Some of the most affluent nations have extremely male biased publication records, despite supposed improvements in gender equality. In addition, we find that most studies focus on economically important crop and model species, and a wealth of biodiversity is underrepresented in the literature. Taken together, our analyses reveal a problematic system of publication, with persistent imbalances that poorly capture the global wealth of scientific knowledge and biological diversity. We conclude by highlighting disparities that can be addressed immediately and offer suggestions for long-term solutions to improve equity in the plant sciences. 

Abstract Hearing loss is the leading sensory deficit, affecting ~ 5% of the population. It exhibits remarkable heterogeneity across 223 genes with 6328 pathogenic missense variants, making deafness-specific expertise a prerequisite for ascribing phenotypic consequences to genetic variants. Deafness-implicated variants are curated in the Deafness Variation Database (DVD) after classification by a genetic hearing loss expert panel and thorough informatics pipeline. However, seventy percent of the 128,167 missense variants in the DVD are “variants of uncertain significance” (VUS) due to insufficient evidence for classification. Here, we use the deep learning protein prediction algorithm, AlphaFold2, to curate structures for all DVD genes. We refine these structures with global optimization and the AMOEBA force field and use DDGun3D to predict folding free energy differences (∆∆G_Fold) for all DVD missense variants. We find that 5772 VUSs have a large, destabilizing ∆∆G_Foldthat is consistent with pathogenic variants. When also filtered for CADD scores (> 25.7), we determine 3456 VUSs are likely pathogenic at a probability of 99.0%. Of the 224 genes in the DVD, 166 genes (74%) exhibit one or more missense variants predicted to cause a pathogenic change in protein folding stability. The VUSs prioritized here affect 119 patients (~ 3% of cases) sequenced by the OtoSCOPE targeted panel. Approximately half of these patients previously received an inconclusive report, and reclassification of these VUSs as pathogenic provides a new genetic diagnosis for six patients.