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Abstract The most massive stars provide an essential source of recycled material for young clusters and galaxies. While very massive stars (VMS, M>100 $$\rm {\rm M}_{\odot }$$) are relatively rare compared to O stars, they lose disproportionately large amounts of mass already from the onset of core H-burning. VMS have optically thick winds with elevated mass-loss rates in comparison to optically thin standard O-star winds. We compute wind yields and ejected masses on the main sequence, and we compare enhanced mass-loss rates to standard ones. We calculate solar metallicity wind yields from MESA stellar evolution models in the range 50 – 500 $$\rm {\rm M}_{\odot }$$, including a large nuclear network of 92 isotopes, investigating not only the CNO-cycle, but also the Ne-Na and Mg-Al cycles. VMS with enhanced winds eject 5-10 times more H-processed elements (N, Ne, Na, Al) on the main sequence in comparison to standard winds, with possible consequences for observed anti-correlations, such as C-N and Na-O, in globular clusters. We find that for VMS 95% of the total wind yields is produced on the main sequence, while only ∼ 5% is supplied by the post-main sequence. This implies that VMS with enhanced winds are the primary source of 26Al, contrasting previous works where classical Wolf-Rayet winds had been suggested to be responsible for Galactic 26Al enrichment. Finally, 200 $$\rm {\rm M}_{\odot }$$ stars eject 100 times more of each heavy element in their winds than 50 $$\rm {\rm M}_{\odot }$$ stars, and even when weighted by an IMF their wind contribution is still an order of magnitude higher than that of 50 $$\rm {\rm M}_{\odot }$$ stars.