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Blurring the Lines between Host and Guest: A Chimeric Receptor Derived from Cucurbituril and Triptycene

https://doi.org/10.1002/anie.201803132

Lu, Xiaoyong; Samanta, Soumen K.; Zavalij, Peter Y.; Isaacs, Lyle (July 2018, Angewandte Chemie International Edition)

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A synthetic transcription factor pair mimic for precise recruitment of an epigenetic modifier to the targeted DNA locus

https://doi.org/10.1039/c9cc09608f

Yu, Zutao; Ai, Mengting; Samanta, Soumen K.; Hashiya, Fumitaka; Taniguchi, Junichi; Asamitsu, Sefan; Ikeda, Shuji; Hashiya, Kaori; Bando, Toshikazu; Pandian, Ganesh N.; et al (February 2020, Chemical Communications)

We developed an epigenetically active, cooperative DNA binding transcription factor platform assisted by cucurbit[7]uril (CB7) host–guest modules. This new type of molecule termed ePIP–HoGu not only mimics the operation of transcription factors as a pair but also recruits the epigenetic modifier to a particular DNA locus.
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Hybrid Molecular Container Based on Glycoluril and Triptycene: Synthesis, Binding Properties, and Triggered Release

https://doi.org/10.1002/chem.201802981

Liu, Wenjin; Lu, Xiaoyong; Xue, Weijian; Samanta, Soumen K.; Zavalij, Peter Y.; Meng, Zihui; Isaacs, Lyle (September 2018, Chemistry - A European Journal)

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