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Mechanical regulation of talin through binding and history-dependent unfolding

https://doi.org/10.1126/sciadv.abl7719

Dahal, Narayan ; Sharma, Sabita ; Phan, Binh ; Eis, Annie ; Popa, Ionel ( July 2022 , Science Advances)

DLC1 locks talin R8 in a mechanically stable state, potentially preventing the inside-out activation of integrins.

Free, publicly-accessible full text available July 15, 2023
Nonexponential kinetics captured in sequential unfolding of polyproteins over a range of loads

https://doi.org/10.1016/j.crstbi.2022.04.003

Chetrit, Einat ; Sharma, Sabita ; Maayan, Uri ; Pelah, Maya Georgia ; Klausner, Ziv ; Popa, Ionel ; Berkovich, Ronen ( January 2022 , Current Research in Structural Biology)

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Does protein unfolding play a functional role in vivo ?

https://doi.org/10.1111/febs.15508

Sharma, Sabita ; Subramani, Smrithika ; Popa, Ionel ( March 2021 , The FEBS Journal)

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