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Creators/Authors contains: "Shenvi, Ryan A"

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  1. ; ; (, Journal of the American Chemical Society)
    Many terpene glycosides exhibit contrasteric patterns of 1,2-diol glycosylation in which the more hindered alcohol bears a sugar; protection of the less hindered alcohol only increases steric repulsion. Here, we report a method for contrasteric glycosylation using a new sugar-linker that forms a cleavable, 10-membered ring with high efficiency, leading to syntheses of cotylenin E, J, and ISIR-050. Linker selection was aided by DFT calculations of side reactions and stereoselectivity, as well as conformational analyses using autoDFT, a Python script that converts SMILES strings to DFT-optimized conformational ensembles. 
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  2. ; (, Accounts of Chemical Research)
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  3. (, ACS Central Science)
  4. ; ; (, Tetrahedron)
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  5. (, Angewandte Chemie International Edition)
    Abstract As the inaugural entry in the new seriesHidden Lives, this Viewpoint Article highlights challenges in early childhood care faced by academicians. Research centers must adapt to societal shifts in family structure, uncertainty around research funding, expanded job responsibilities and upheavals brought about by the pandemic. These problems represent opportunities for change at the technological, cultural and policy levels. It is crucial that we recognize those in need and help where we can. 
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  6. ; (, Nature)
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  7. ; ; ; ; ; (, Science)
    Stitching and then reducing aromatic building blocks offers an efficient route into alkaloids found in Galbulimima bark. 
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  8. ; (, Accounts of Chemical Research)
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  9. ; ; (, Tetrahedron Letters)
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  10. ; ; (, Natural Product Reports)
    Covering: 2000 to 2020 The hallucinogenic diterpene salvinorin A potently and selectively agonizes the human kappa-opioid receptor (KOR). Its unique attributes-lack of a basic nitrogen, rapid brain penetrance, short half-life-combined with the potential of KOR as an emerging target for analgesics have stimulated extensive medicinal chemistry based on semi-synthesis from extracts of Salvia divinorum . Total synthesis efforts have delivered multiple, orthogonal routes to salvinorin A, its congeners and related analogs with the goal of optimizing its activity towards multiple functional endpoints. Here we review total syntheses of the salvinorin chemotype and discuss outstanding problems that synthesis can address in the future. 
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