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Abstract Apicomplexa are ancient and diverse organisms which have been poorly characterized by modern genomics. To better understand the evolution and diversity of these single-celled eukaryotes, we sequenced the genome ofOphryocystis elektroscirrha, a parasite of monarch butterflies,Danaus plexippus. We contextualize our newly generated resources within apicomplexan genomics before answering longstanding questions specific to this host-parasite system. To start, the genome is miniscule, totaling only 9 million bases and containing fewer than 3,000 genes, half the gene content of two other sequenced invertebrate-infecting apicomplexans,Porospora giganteaandGregarina niphandrodes. We found thatO. elektroscirrhashares different orthologs with each sequenced relative, suggesting the true set of universally conserved apicomplexan genes is very small indeed. Next, we show that sequencing data from other potential host butterflies can be used to diagnose infection status as well as to study diversity of parasite sequences. We recovered a similarly sized parasite genome from another butterfly,Danaus chrysippus, that was highly diverged from theO. elektroscirrhareference, possibly representing a distinct species. Using these two new genomes, we investigated potential evolutionary response by parasites to toxic phytochemicals their hosts ingest and sequester. Monarch butterflies are well-known to tolerate toxic cardenolides thanks to changes in the sequence of their Type II ATPase sodium pumps. We show thatOphryocystiscompletely lacks Type II or Type 4 sodium pumps, and related proteins PMCA calcium pumps show extreme sequence divergence compared to other Apicomplexa, demonstrating new avenues of research opened by genome sequencing of non-model Apicomplexa. 

Abstract Observational evidence shows changes to North American weather regime occurrence depending on the strength of the lower-stratospheric polar vortex. However, it is not yet clear how this occurs or to what extent an improved stratospheric forecast would change regime predictions. Here we analyze four North American regimes at 500 hPa, constructed in principal component (PC) space. We consider both the location of the regimes in PC space and the linear regression between each PC and the lower-stratospheric zonal-mean winds, yielding a theory of which regime transitions are likely to occur due to changes in the lower stratosphere. Using a set of OpenIFS simulations, we then test the effect of relaxing the polar stratosphere to ERA-Interim on subseasonal regime predictions. The model start dates are selected based on particularly poor subseasonal regime predictions in the European Centre for Medium-Range Weather Forecasts CY43R3 hindcasts. While the results show only a modest improvement to the number of accurate regime predictions, there is a substantial reduction in Euclidean distance error in PC space. The average movement of the forecasts within PC space is found to be consistent with expectation for moderate-to-large lower-stratospheric zonal wind perturbations. Overall, our results provide a framework for interpreting the stratospheric influence on North American regime behavior. The results can be applied to subseasonal forecasts to understand how stratospheric uncertainty may affect regime predictions, and to diagnose which regime forecast errors are likely to be related to stratospheric errors. Significance Statement Predicting the weather several weeks ahead is a major challenge with large potential benefits to society. The strength of the circulation more than 10 km above the Arctic during winter (i.e., the polar vortex) is one source of predictability. This study investigates how forecast error and uncertainty in the polar vortex can impact predictions of large-scale weather patterns called “regimes” over North America. Through statistical analysis of observations and experiments with a weather forecast model, we develop an understanding of which regime changes are more likely to be due to changes in the polar vortex. The results will help forecasters and researchers understand the contribution of the stratosphere to changes in weather patterns, and in assessing and improving weather forecast models. 

Properties of the nuclear equation of state (EoS) can be probed by measuring the dynamical properties of nucleus-nucleus collisions. In this study, we present the directed flow (v1), elliptic flow (v2) and stopping (VarXZ) measured in fixed target Sn+ Sn collisions at 270AMeV with the S'll'RlT Time Projection Chamber. We perform Bayesian analyses in which EoS parameters are var­ied simultaneously within the Improved Quantum Molecular Dynamics-Skyrme (ImQMD-Sky) transport code to obtain a multivariate correlated constraint. The varied parameters include symmetry energy, S0, and slope of the symme­try energy, L, at saturation density, isoscalar effective mass, m;/mN, isovector effective mass, m􀀒/mN and the in-medium cross-section enhancement factor rJ. We find that the flow and VarXZ observables are sensitive to the splitting of proton and neutron effective masses and the in-medium cross-section. Compar­isons of ImQMD-Sky predictions to the S'll' RJT data suggest a narrow range of preferred values for m;/mN, m􀀕/mN and 1/· 

The separation of xylene isomers still remains an industrially challenging task. Here, porous purine-based metal–organic frameworks (MOFs) have been synthesized and studied for their potential in xylene separations. In particular, Zn(purine)I showed excellent para -xylene/ ortho -xylene separation capability with a diffusion selectivity of 6 and high equilibrium adsorption selectivity as indicated by coadsorption experiments. This high selectivity is attributed to the shape and size of the channel aperture within the rigid framework of Zn(purine)I. 

We report the confirmation and characterisation of TOI-1820 b, TOI-2025 b, and TOI-2158 b, three Jupiter-sized planets on short-period orbits around G-type stars detected by TESS. Through our ground-based efforts using the FIES and Tull spectrographs, we have confirmed these planets and characterised their orbits, and find periods of around 4.9 d, 8.9 d, and 8.6 d for TOI-1820 b, TOI-2025 b, and TOI-2158 b, respectively. The sizes of the planets range from 0.96 to 1.14 Jupiter radii, and their masses are in the range from 0.8 to 4.4 Jupiter masses. For two of the systems, namely TOI-2025 and TOI-2158, we see a long-term trend in the radial velocities, indicating the presence of an outer companion in each of the two systems. For TOI-2025 we furthermore find the star to be well aligned with the orbit, with a projected obliquity of 9 −31 +33 °. As these planets are all found in relatively bright systems ( V ~ 10.9–11.6 mag), they are well suited for further studies, which could help shed light on the formation and migration of hot and warm Jupiters.