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Abstract pyspeckit is a toolkit and library for spectroscopic analysis in Python. We describe thepyspeckit package and highlight some of its capabilities, such as interactively fitting a model to data, akin to the historically widely-usedsplot function inIRAF .pyspeckit employs the Levenberg–Marquardt optimization method via thempfit andlmfit implementations, and important assumptions regarding error estimation are described here. Wrappers to usepymc andemcee as optimizers are provided. A parallelized wrapper to fit lines in spectral cubes is included. As part of theastropy affiliated package ecosystem,pyspeckit is open source and open development, and welcomes input and collaboration from the community.