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Abstract What have language models (LMs) learned about grammar? This question remains hotly debated, with major ramifications for linguistic theory. However, since probability and grammaticality are distinct notions in linguistics, it is not obvious what string probabilities can reveal about an LM’s underlying grammatical knowledge. We present a theoretical analysis of the relationship between grammar, meaning, and string probability, based on simple assumptions about the generative process of corpus data. Our framework makes three predictions, which we validate empirically using 280K sentence pairs in English and Chinese: (1) correlation between the probability of strings within minimal pairs, i.e., string pairs with minimal semantic differences; (2) correlation between models’ and humans’ deltas within minimal pairs; and (3) poor separation in probability space between unpaired grammatical and ungrammatical strings. Our analyses give theoretical grounding for using probability to learn about LMs’ structural knowledge, and suggest directions for future work in LM grammatical evaluation. 

Abstract The LAT1-4F2hc complex (SLC7A5-SLC3A2) facilitates uptake of essential amino acids, hormones and drugs. Its dysfunction is associated with many cancers and immune/neurological disorders. Here, we apply native mass spectrometry (MS)-based approaches to provide evidence of super-dimer formation (LAT1-4F2hc)₂. When combined with lipidomics, and site-directed mutagenesis, we discover four endogenous phosphatidylethanolamine (PE) molecules at the interface and C-terminus of both LAT1 subunits. We find that interfacial PE binding is regulated by 4F2hc-R183 and is critical for regulation of palmitoylation on neighbouring LAT1-C187. Combining native MS with mass photometry (MP), we reveal that super-dimerization is sensitive to pH, and modulated by complex N-glycans on the 4F2hc subunit. We further validate the dynamic assemblies of LAT1-4F2hc on plasma membrane and in the lysosome. Together our results link PTM and lipid binding with regulation and localisation of the LAT1-4F2hc super-dimer. 

Abstract Image Advances in the synthesis and self-assembly of nanocrystals have enabled researchers to create a plethora of different nanoparticle superlattices. But while many superlattices with complex types of translational order have been realized, rotational order of nanoparticle building blocks within the lattice is more difficult to achieve. Self-assembled superstructures with atomically coherent nanocrystal lattices, which are desirable due to their exceptional electronic and optical properties, have been fabricated only for a few selected systems. Here, we combine experiments with molecular dynamics (MD) simulations to study the self-assembly of heterostructural nanocrystals (HNCs), consisting of a near-spherical quantum dot (QD) host decorated with a small number of epitaxially grown gold nanocrystal (Au NC) “patches”. Self-assembly of these HNCs results in face-centered-cubic (fcc) superlattices with well-defined orientational relationships between the atomic lattices of both QD hosts and Au patches. MD simulations indicate that the observed dual atomic coherence is linked to the number, size, and relative positions of gold patches. This study provides a strategy for the design and fabrication of NC superlattices with large structural complexity and delicate orientational order.