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Ascospores generated during sexual reproduction are the primary inoculum for the wheat scab fungus Fusarium graminearum. Purine metabolism is known to play important roles in fungal pathogens but its lifecycle stage-specific regulation is unclear. By characterizing the genes involved in purine de novo and salvage biosynthesis pathways, we showed that de novo syntheses of inosine, adenosine and guanosine monophosphates (IMP, AMP and GMP) are important for vegetative growth, sexual/asexual reproduction, and infectious growth, whereas purine salvage synthesis is dispensable for these stages in F. graminearum. Addition of GMP rescued the defects of the Fgimd1 mutant in vegetative growth and conidiationmore »
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This proceeding was published in a special issue of J. Laser Appl. as: H. Cheng, C. Xia, S. M. Kuebler, P. Golvari, M. Sun, M. Zhang, X. Yu*. "Generation of Bessel-beam arrays for parallel fabrication in two-photon polymerization." J. Laser Appl. 2021, 33, 012040-1 - 012040-6; https://doi.org/10.2351/7.0000313.