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A Behavioral Model for Transcutaneous Carbon Dioxide Measurement Using Time-Correlated Single Photon Counting Technique

https://doi.org/10.1109/EMBC53108.2024.10782349

Isiksalan, Isil; Karli, Hakan B; Tufan, Tuna B; Matthews, John; Unluturk, Bige D; Guler, Ulkuhan (July 2024, IEEE)

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Implementation Techniques for Transcutaneous Carbon Dioxide Monitoring: Approaches for Wearable Smart Health Applications

https://doi.org/10.1109/TBME.2023.3322871

Tufan, Tuna B.; Rhein, Lawrence; Guler, Ulkuhan (March 2024, IEEE Transactions on Biomedical Engineering)

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A Transcutaneous Carbon Dioxide Monitor Based on Time-Domain Dual Lifetime Referencing

https://doi.org/10.1109/TBCAS.2023.3277398

Tufan, Tuna B.; Guler, Ulkuhan (August 2023, IEEE Transactions on Biomedical Circuits and Systems)

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A Miniaturized Transcutaneous Carbon Dioxide Monitor Based on Dual Lifetime Referencing

https://doi.org/10.1109/BioCAS54905.2022.9948600

Tufan, Tuna B.; Guler, Ulkuhan (October 2022, 2022 IEEE Biomedical Circuits and Systems Conference (BioCAS))

The ability to monitor blood gases, namely oxy-gen and carbon dioxide, in real-time is of critical importance to clinicians in diagnosing and treating respiratory disorders. Transcutaneous monitors measure the partial pressure of carbon dioxide diffused from the skin. These monitors are noninvasive and capable of continuously monitoring carbon dioxide. Conventional transcutaneous carbon dioxide monitors require a heating element and large calibration equipment for reliable measurements. We propose a miniaturized transcutaneous carbon dioxide monitor based on a luminescence sensing film and dual lifetime referencing technique to assess the partial pressure of carbon dioxide within the 0-75 mmHg range, covering the clinically relevant range for healthy humans, 35-45 mmHg. We measured the partial pressure of carbon dioxide with less than ~1.6% error in the given range without any post-processing and heating.
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