skip to main content

Search for: All records

Creators/Authors contains: "Tyson, R."

Note: When clicking on a Digital Object Identifier (DOI) number, you will be taken to an external site maintained by the publisher. Some full text articles may not yet be available without a charge during the embargo (administrative interval).
What is a DOI Number?

Some links on this page may take you to non-federal websites. Their policies may differ from this site.

  1. Free, publicly-accessible full text available September 1, 2022
  2. Free, publicly-accessible full text available June 1, 2023
  3. Free, publicly-accessible full text available April 1, 2023
  4. Structural DNA nanotechnology is beginning to emerge as a widely accessible research tool to mechanistically study diverse biophysical processes. Enabled by scaffolded DNA origami in which a long single strand of DNA is weaved throughout an entire target nucleic acid assembly to ensure its proper folding, assemblies of nearly any geometric shape can now be programmed in a fully automatic manner to interface with biology on the 1–100-nm scale. Here, we review the major design and synthesis principles that have enabled the fabrication of a specific subclass of scaffolded DNA origami objects called wireframe assemblies. These objects offer unprecedented controlmore »over the nanoscale organization of biomolecules, including biomolecular copy numbers, presentation on convex or concave geometries, and internal versus external functionalization, in addition to stability in physiological buffer. To highlight the power and versatility of this synthetic structural biology approach to probing molecular and cellular biophysics, we feature its application to three leading areas of investigation: light harvesting and nanoscale energy transport, RNA structural biology, and immune receptor signaling, with an outlook toward unique mechanistic insight that may be gained in these areas in the coming decade.« less
  5. Free, publicly-accessible full text available February 1, 2023
  6. Free, publicly-accessible full text available February 1, 2023
  7. Free, publicly-accessible full text available January 1, 2023
  8. Free, publicly-accessible full text available December 1, 2022
  9. Free, publicly-accessible full text available December 1, 2022
  10. Free, publicly-accessible full text available November 25, 2022