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Hyperdimensional computing (HD) is an emerging brain-inspired paradigm used for machine learning classification tasks. It manipulates ultra-long vectors-hypervectors- using simple operations, which allows for fast learning, energy efficiency, noise tolerance, and a highly parallel distributed framework. HD computing has shown a significant promise in the area of biological signal classification. This paper addresses group-specific premature ventricular contraction (PVC) beat detection with HD computing using the data from the MIT-BIH arrhythmia database. Temporal, heart rate variability (HRV), and spectral features are extracted, and minimal redundancy maximum relevance (mRMR) is used to rank and select features for classification. Three encoding approaches are explored for mapping the features into the HD space. The HD computing classifiers can achieve a PVC beat detection accuracy of 97.7 % accuracy, compared to 99.4% achieved by more computationally complex methods such as convolutional neural networks (CNNs).