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N , N -Alkylation Clarifies the Role of N - and O -Protonated Intermediates in Cyclen-Based ⁶⁴ Cu Radiopharmaceuticals

https://doi.org/10.1021/acs.inorgchem.2c02907

Brown, Alexander M.; Butman, Jana L.; Lengacher, Raphael; Vargo, Natasha P.; Martin, Kirsten E.; Koller, Angus; Śmiłowicz, Dariusz; Boros, Eszter; Robinson, Jerome R. (January 2023, Inorganic Chemistry)

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Thiolate-Thione Redox-Active Ligand with a Six-Membered Chelate Ring via Template Condensation and Its Pt(II) Complexes

https://doi.org/10.1021/acs.inorgchem.1c01693

Zuckerman, Linda A.; Vargo, Natasha P.; May, Claire V.; Crockett, Michael P.; Hyre, Ariel S.; McNeely, James; Elinburg, Jessica K.; Brown, Alexander M.; Robinson, Jerome R.; Rheingold, Arnold L.; et al (September 2021, Inorganic Chemistry)
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Calcium‐Ion Binding Mediates the Reversible Interconversion of Cis and Trans Peroxido Dicopper Cores

https://doi.org/10.1002/anie.202105421

Vargo, Natasha P.; Harland, Jill B.; Musselman, Bradley W.; Lehnert, Nicolai; Ertem, Mehmed Z.; Robinson, Jerome R. (July 2021, Angewandte Chemie International Edition)

Abstract Coupled dinuclear copper oxygen cores (Cu₂O₂) featured in type III copper proteins (hemocyanin, tyrosinase, catechol oxidase) are vital for O₂transport and substrate oxidation in many organisms.μ‐1,2‐cisperoxido dicopper cores (^CP) have been proposed as key structures in the early stages of O₂binding in these proteins; their reversible isomerization to other Cu₂O₂cores are directly relevant to enzyme function. Despite the relevance of such species to type III copper proteins and the broader interest in the properties and reactivity of bimetallic^CPcores in biological and synthetic systems, the properties and reactivity of^CPCu₂O₂species remain largely unexplored. Herein, we report the reversible interconversion ofμ‐1,2‐transperoxido (^TP) and^CPdicopper cores. Ca^IImediates this process by reversible binding at the Cu₂O₂core, highlighting the unique capability for metal‐ion binding events to stabilize novel reactive fragments and control O₂activation in biomimetic systems.
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