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only short abstract available on SPIE website; but the video of the presentation is available 

Not AvaIn this study, a novel near-infrared (NIR) ICG-based J-aggregate contrast agent was used for photoacoustic tomography (PAT) to image whole organs in a nude mouse model. NIR-PAT obtained at the 895-nm absorption peak of our nanoparticles, we were able to resolve organs of interest that included the liver and kidney along with vasculature deeper into biological tissue while maintaining fine spatial resolution. NIR-PAT shows promising applications in small-animal functional imaging, including measuring oxygen saturation levels and studying biodistribution of contrast agents, leading to potential clinical imaging studies for drug development and delivery, and angiographic studies.ilable 

Abstract Synapses contain hundreds of distinct proteins whose heterogeneous expression levels are determinants of synaptic plasticity and signal transmission relevant to a range of diseases. Here, we use diffusible nucleic acid imaging probes to profile neuronal synapses using multiplexed confocal and super-resolution microscopy. Confocal imaging is performed using high-affinity locked nucleic acid imaging probes that stably yet reversibly bind to oligonucleotides conjugated to antibodies and peptides. Super-resolution PAINT imaging of the same targets is performed using low-affinity DNA imaging probes to resolve nanometer-scale synaptic protein organization across nine distinct protein targets. Our approach enables the quantitative analysis of thousands of synapses in neuronal culture to identify putative synaptic sub-types and co-localization patterns from one dozen proteins. Application to characterize synaptic reorganization following neuronal activity blockade reveals coordinated upregulation of the post-synaptic proteins PSD-95, SHANK3 and Homer-1b/c, as well as increased correlation between synaptic markers in the active and synaptic vesicle zones.