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Real-time semantic segmentation and anomaly detection of functional images for cell therapy manufacturing

https://doi.org/10.1016/j.jcyt.2023.08.011

Chen, Rui Qi; Joffe, Benjamin; Casteleiro_Costa, Paloma; Filan, Caroline; Wang, Bryan; Balakirsky, Stephen; Robles, Francisco; Roy, Krishnendu; Li, Jing (December 2023, Cytotherapy)

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Digital Twin Design for hMSC Expansion in Hollow-fiber Bioreactors

https://doi.org/10.23919/ACC55779.2023.10156514

Kanwar, Bharat; Wang, Bryan; Roy, Krishnendu; Mazumdar, Anirban; Balakirsky, Stephen (May 2023, IEEE)

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Early detection and metabolic pathway identification of T cell activation by in-process intracellular mass spectrometry

https://doi.org/10.1016/j.jcyt.2023.03.010

Culberson, Austin L; Bowles-Welch, Annie C; Wang, Bryan; Kottke, Peter A; Jimenez, Angela C; Roy, Krishnendu; Fedorov, Andrei G (September 2023, Cytotherapy)

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Cell type–specific microRNA therapies for myocardial infarction

https://doi.org/10.1126/scitranslmed.abd0914

Liu, Bohao; Wang, Bryan; Zhang, Xiaokan; Lock, Roberta; Nash, Trevor; Vunjak-Novakovic, Gordana (February 2021, Science Translational Medicine)

Current interventions fail to recover injured myocardium after infarction and prompt the need for development of cardioprotective strategies. Of increasing interest is the therapeutic use of microRNAs to control gene expression through specific targeting of mRNAs. In this Review, we discuss current microRNA-based therapeutic strategies, describing the outcomes and limitations of key microRNAs with a focus on target cell types and molecular pathways. Last, we offer a perspective on the outlook of microRNA therapies for myocardial infarction, highlighting the outstanding challenges and emerging strategies.
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