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Creators/Authors contains: "Wang, Lianchun"

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  1. ; ; ; ; ; ; ; ; ; ; et al (, Carbohydrate Polymers)
    Free, publicly-accessible full text available March 1, 2026
  2. ; ; ; ; ; ; ; ; ; ; et al (, Journal of Biological Chemistry)
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  3. ; ; ; ; ; ; ; ; (, Carbohydrate Polymers)
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  4. ; ; ; ; ; ; ; ; ; ; et al (, Science Advances)
    HS3ST1is a genetic risk gene associated with Alzheimer’s disease (AD) and overexpressed in patients, but how it contributes to the disease progression is unknown. We report the analysis of brain heparan sulfate (HS) from AD and other tauopathies using a LC-MS/MS method. A specific 3-O-sulfated HS displayed sevenfold increase in the AD group (n= 14,P< 0.0005). Analysis of the HS modified by recombinant sulfotransferases and HS from genetic knockout mice revealed that the specific 3-O-sulfated HS is made by 3-O-sulfotransferase isoform 1 (3-OST-1), which is encoded by theHS3ST1gene. A synthetic tetradecasaccharide (14-mer) carrying the specific 3-O-sulfated domain displayed stronger inhibition for tau internalization than a 14-mer without the domain, suggesting that the 3-O-sulfated HS is used in tau cellular uptake. Our findings suggest that the overexpression ofHS3ST1gene may enhance the spread of tau pathology, uncovering a previously unidentified therapeutic target for AD. 
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