The Cayo Santiago rhesus macaque colony represents one of the most important nonhuman primate resources since their introduction to the Caribbean area in 1938. The 85 years of continuing existence along with the comprehensive database of the rhesus colony and the derived skeletal collections have provided and will continue to provide a powerful tool to test hypotheses about adaptive and evolutionary mechanisms in both biology and medicine.
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Bales, Karen (Ed.)
Abstract Free, publicly-accessible full text available July 4, 2025 -
Abstract Cupin dioxygenases such as salicylate 1,2‐dioxygense (SDO) perform aromatic C−C bond scission via a 3‐His motif tethered iron cofactor. Here, transient kinetics measurements are used to monitor the catalytic cycle of SDO by using a nitro‐substituted substrate analog, 3‐nitrogentisate. Compared to the natural substrate, the nitro group reduces the enzymatic
k catby 500‐fold, thereby facilitating the detection and kinetic characterization of reaction intermediates. Sums and products of reciprocal relaxation times derived from kinetic measurements were found to be linearly dependent on O2concentration, suggesting reversible formation of two distinct intermediates. Dioxygen binding to the metal cofactor takes place with a forward rate of 5.9×103 M−1 s−1: two orders of magnitude slower than other comparable ring‐cleaving dioxygenses. Optical chromophore of the first intermediate is distinct from thein situ generated SDO Fe(III)−O2⋅−complex but closer to the enzyme‐substrate precursor.Free, publicly-accessible full text available April 16, 2025 -
The rich records of Rhesus macaques at Cayo Santiago (CS) with detailed information of individual and family relationships enables extended genetic analyses of the reproductive history of the colony. As a part of a collaborative effort to build a Knowledge Model of the history of health of the CS Rhesus colony, this study further delves into the intricate social group interactions and reproduction dynamics to provide an integrated perspective for a deeper understanding of familial connections and genetic aggregations. Leveraging matrilineal lineage developed from previous work and patrilineal tracing made available since mid-1970’s, as well as inter-group transfer data, this study attempted to provide retrospective views of group evolution history, with an emphasis on dyad interactions regarding their natal and transferred groups. Employing tools and techniques popular in social community analysis, including graph database and Gephi, this study conducted a comparative analysis focused on animals born between 2005 and 2014. Preliminary results indicated that communities identified by using Gephi matched well with census records, while deviations from historical sketches of group evolution summaries existed as well. Upcoming results from using Neo4j, a graph database system, will be compared with these findings, which can be integrated more smoothly with CSViewer for Analysts, the graphical user interfaces for the CS Knowledge Model to be introduced in a workshop at AABA 2024 annual meeting. Findings of this research can help add one more perspective to pathological studies seeking correlations with environmental factors such as food provision and natural disasters like hurricanes.more » « lessFree, publicly-accessible full text available March 21, 2025
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Abstract--The Cayo Santiago rhesus, established and maintained for 85 years, has evolved into a valuable resource for researchers across various disciplines. This research paper outlines an ongoing NSF project aimed at developing a comprehensive database and user-friendly software application, CSViewer, to uncover hidden knowledge. Using a big data approach, the paper focuses on key events in the colony's population dynamics, emphasizing gender-specific analyses. It also explores data exploration and preparation processes, along with the application of the genealogy model in inbreeding analysis and genetic tracing. Future efforts, including the expansion of CSViewer's functions, are also addressed.more » « less
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Turner, Trudy (Ed.)
Abstract Objectives This brief communication documents the prevalence of maxillary central incisor talon cusps in Cayo Santiago rhesus monkeys (
Macaca mulatta ) and assesses whether talon cusp presence occurs at equivalent frequencies across matrilines.Materials and Methods The data on cusp presence vs. absence were analyzed by logistic regression in 170 monkeys (82 females, 78 males) from seven different matrilines. Sample sizes per matriline ranged from 10 to 42. Observations of talon cusps were blind with respect to matriline and sex.
Results Talon cusps were present in 9.4% of the sample. By matriline, cusp frequencies ranged from 0%—Matrilines 073 and 106%—to 19.1% in Matriline 076. The frequency of the talon cusp in Matriline 076 was significantly greater than the frequency of the cusp in the remainder of the sample. There was no statistically significant difference in the frequency of the talon cusp by sex.
Conclusions This study suggests that the talon cusp in rhesus monkeys, as in humans and baboons, is a rare trait. Elevated prevalence of the talon cusp in Matriline 076 suggests the possibility of a genetic influence on talon cusp expression.