Search for: All records

Memory disaggregation (MD) allows for scalable and elastic data center design by separating compute (CPU) from memory. With MD, compute and memory are no longer coupled into the same server box. Instead, they are connected to each other via ultra-fast networking such as RDMA. MD can bring many advantages, e.g., higher memory utilization, better independent scaling (of compute and memory), and lower cost of ownership. This paper makes the case that MD can fuel the next wave of innovation on database systems. We observe that MD revives the great debate of shared what in the database community. We envision thatdistributed shared-memory databases (DSM-DB, for short)- that have not received much attention before - can be promising in the future with MD. We present a list of challenges and opportunities that can inspire next steps in system design making the case for DSM-DB. 

Abstract Over the last 20 years, N-heterocyclic carbenes (NHCs) have emerged as a dominant direction in ligand development in transition metal catalysis. In particular, strong σ-donation in combination with tunable steric environment make NHCs to be among the most common ligands used for C–C and C–heteroatom bond formation. Herein, we report the study on steric and electronic properties of thiazol-2-ylidenes. We demonstrate that the thiazole heterocycle and enhanced π-electrophilicity result in a class of highly active carbene ligands for electrophilic cyclization reactions to form valuable oxazoline heterocycles. The evaluation of steric, electron-donating and π-accepting properties as well as structural characterization and coordination chemistry is presented. This mode of catalysis can be applied to late-stage drug functionalization to furnish attractive building blocks for medicinal chemistry. Considering the key role of N-heterocyclic ligands, we anticipate thatN-aryl thiazol-2-ylidenes will be of broad interest as ligands in modern chemical synthesis. 

Abstract Although cross‐coupling reactions of amides by selective N−C cleavage are one of the most powerful and burgeoning areas in organic synthesis due to the ubiquity of amide bonds, the development of mechanochemical, solid‐state methods remains a major challenge. Herein, we report the first mechanochemical strategy for highly chemoselective, solvent‐free palladium‐catalyzed cross‐coupling of amides by N−C bond activation. The method is conducted in the absence of external heating, for short reaction time and shows excellent chemoselectivity for σ N−C bond activation. The reaction shows excellent functional group tolerance and can be applied to late‐stage functionalization of complex APIs and sequential orthogonal cross‐couplings exploiting double solventless solid‐state methods. The results extend mechanochemical reaction environments to advance the chemical repertoire of N−C bond interconversions to solid‐state environmentally friendly mechanochemical methods.