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DNA has shown great biocompatibility, programmable mechanical properties, and precise structural addressabil- ity at the nanometer scale, rendering it a material for constructing versatile nanorobots for biomedical applica- tions. Here, we present the design principle, synthesis, and characterization of a DNA nanorobotic hand, called DNA NanoGripper, that contains a palm and four bendable fingers as inspired by naturally evolved human hands, bird claws, and bacteriophages. Each NanoGripper finger consists of three phalanges connected by three rotat- able joints that are bendable in response to the binding of other entities. NanoGripper functions are enabled and driven by the interactions between moieties attached to the fingers and their binding partners. We demonstrate that the NanoGripper can be engineered to effectively interact with and capture nanometer-scale objects, includ- ing gold nanoparticles, gold NanoUrchins, and SARS-CoV-2 virions. With multiple DNA aptamer nanoswitches programmed to generate a fluorescent signal that is enhanced on a photonic crystal platform, the NanoGripper functions as a highly sensitive biosensor that selectively detects intact SARS-CoV-2 virions in human saliva with a limit of detection of ~100 copies per milliliter, providing a sensitivity equal to that of reverse transcription quanti- tative polymerase chain reaction (RT-qPCR). Quantified by flow cytometry assays, we demonstrated that the NanoGripper-aptamer complex can effectively block viral entry into the host cells, suggesting its potential for in- hibiting virus infections. The design, synthesis, and characterization of a sophisticated nanomachine that can be tailored for specific applications highlight a promising pathway toward feasible and efficient solutions to the de- tection and potential inhibition of virus infections. 

The rapidly increasing size of deep-learning models has renewed interest in alternatives to digital-electronic computers as a means to dramatically reduce the energy cost of running state-of-the-art neural networks. Optical matrix-vector multipliers are best suited to performing computations with very large operands, which suggests that large Transformer models could be a good target for them. In this paper, we investigate---through a combination of simulations and experiments on prototype optical hardware---the feasibility and potential energy benefits of running Transformer models on future optical accelerators that perform matrix-vector multiplication. We use simulations, with noise models validated by small-scale optical experiments, to show that optical accelerators for matrix-vector multiplication should be able to accurately run a typical Transformer architecture model for language processing. We demonstrate that optical accelerators can achieve the same (or better) perplexity as digital-electronic processors at 8-bit precision, provided that the optical hardware uses sufficiently many photons per inference, which translates directly to a requirement on optical energy per inference. We studied numerically how the requirement on optical energy per inference changes as a function of the Transformer width $d$ and found that the optical energy per multiply--accumulate (MAC) scales approximately as $\frac{1}{d}$, giving an asymptotic advantage over digital systems. We also analyze the total system energy costs for optical accelerators running Transformers, including both optical and electronic costs, as a function of model size. We predict that well-engineered, large-scale optical hardware should be able to achieve a $100 \times$ energy-efficiency advantage over current digital-electronic processors in running some of the largest current Transformer models, and if both the models and the optical hardware are scaled to the quadrillion-parameter regime, optical accelerators could have a $>8,000\times$ energy-efficiency advantage. Under plausible assumptions about future improvements to electronics and Transformer quantization techniques (5× cheaper memory access, double the digital--analog conversion efficiency, and 4-bit precision), we estimate that the energy advantage for optical processors versus electronic processors operating at 300~fJ/MAC could grow to $>100,000\times$. 

Artificial Intelligence is poised to transform the design of complex, large-scale detectors like ePIC at the future Electron Ion Collider. Featuring a central detector with additional detecting systems in the far forward and far backward regions, the ePIC experiment incorporates numerous design parameters and objectives, including performance, physics reach, and cost, constrained by mechanical and geometric limits.This project aims to develop a scalable, distributed AI-assisted detector design for the EIC (AID(2)E), employing state-of-the-art multiobjective optimization to tackle complex designs. Supported by the ePIC software stack and usingGeant4simulations, our approach benefits from transparent parameterization and advanced AI features.The workflow leverages the PanDA and iDDS systems, used in major experiments such as ATLAS at CERN LHC, the Rubin Observatory, and sPHENIX at RHIC, to manage the compute intensive demands of ePIC detector simulations. Tailored enhancements to the PanDA system focus on usability, scalability, automation, and monitoring.Ultimately, this project aims to establish a robust design capability, apply a distributed AI-assisted workflow to the ePIC detector, and extend its applications to the design of the second detector (Detector-2) in the EIC, as well as to calibration and alignment tasks. Additionally, we are developing advanced data science tools to efficiently navigate the complex, multidimensional trade-offs identified through this optimization process.