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  1. Free, publicly-accessible full text available January 1, 2023
  2. Despite providing convenience and reducing the travel burden of patients, Video-Conferencing (VC) clinical visits have not enjoyed wide uptake by patients and care providers. It is desired that the medical problems addressed by VC visits can match a face-to-face encounter in scope and quality. Subsequently, VC visits with nurse assistance are emerging; however, the scalable and financially sustainable of such services are unclear. Therefore, we explore the implementability of VC visits with nursing services using a game-theoretic model, and investigate the impact of different pricing schemes (discriminative pricing based on patient characteristics vs. non-discriminative) on patients’ care choices between VCmore »and in-person visits. Our results shed light on the “artificial congestion” created by a profit-driven medical institution that hurts patient welfare, and subsequently identify the conditions where the interest of the social planner and the medical institution are aligned. Our results highlight that, compared to a uniform price of VC visits which seems fair, discriminative pricing can be more beneficial for patients and the medical institution alike. This heightens the importance of insurance coverage of telehealth-related services to promote the adoption of telehealth by patients and care providers, and ultimately, improving care access and patient outcomes.« less
    Free, publicly-accessible full text available October 28, 2022
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  4. Free, publicly-accessible full text available September 1, 2022
  5. Protein transfer into nanoscale compartments is critical for many cellular/life processes, yet there are few reports on how compartment properties impact the protein orientation during a transfer. Such a knowledge gap limits a deeper understanding of the protein transfer mechanism, which could be bridged using nanoporous materials. Here, we use a mesoporous silica, a covalent organic framework, and a metal-organic framework with charged, hydrophobic, and neutral surfaces, respectively, to elucidate the impact of channel properties on the transfer of a model protein, lysozyme. Using site-directed spin labeling and time-resolved electron paramagnetic resonance spectroscopy, we reveal that the transfer can bemore »a multi-step process depending on channel properties and depict the relative orientation changes of lysozyme upon transfer into each channel. To the best of our knowledge, this is the first structural insight into protein orientation upon transfer into different compartments, meaningful for the rational design of synthetic materials to host enzymes or mimic the cellular compartments.« less
    Free, publicly-accessible full text available September 22, 2022
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