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  1. The gut is a well-established route of infection and target for viral damage by SARSCoV-2. This is supported by the clinical observation that about half of COVID-19 patients exhibit gastrointestinal (GI) symptoms. We asked whether the analysis of plasma could provide insight into gut barrier dysfunction in patients with COVID-19 infection. Plasma samples of COVID-19 patients (n=30) and healthy control (n=16) were collected during hospitalization. Plasma microbiome was analyzed using 16S rRNA sequencing, metatranscriptomic analysis, and gut permeability markers including FABP-2, PGN and LPS in both patient cohorts. Almost 65% (9 out 14) COVID-19 patients showed abnormal presence of gutmore »microbes in their bloodstream. Plasma samples contained predominately Proteobacteria, Firmicutes, and Actinobacteria. The abundance of gram-negative bacteria (Acinetobacter, Nitrospirillum, Cupriavidus, Pseudomonas, Aquabacterium, Burkholderia, Caballeronia, Parabhurkholderia, Bravibacterium, and Sphingomonas) was higher than the gram-positive bacteria (Staphylococcus and Lactobacillus) in COVID-19 subjects. The levels of plasma gut permeability markers FABP2 (1282±199.6 vs 838.1±91.33; p=0.0757), PGN (34.64±3.178 vs 17.53±2.12; p<0.0001), and LPS (405.5±48.37 vs 249.6±17.06; p=0.0049) were higher in COVID-19 patients compared to healthy subjects. These findings support that the intestine may represent a source for bacteremia and may contribute to worsening COVID-19 outcomes. Therapies targeting the gut and prevention of gut barrier defects may represent a strategy to improve outcomes in COVID19 patients.« less
  2. This paper analyzes the damping and stiffness terms of a 4-degree of freedom laboratory scale electrodynamic wheel magnetic levitation vehicle. The vehicle creates both suspension and propulsion forces through the simultaneous rotation and translation of the electrodynamic wheels above a conductive non-magnetic plate of finite thickness. The stiffness and damping terms were derived using an analytic 3-D steady-state eddy current model, and are analyzed based on their suitability for a linear state-space model. The implications with respect to static stability are discussed.
  3. A faint star located 2 arcsec from KIC 8462852 was discovered in Keck 10 m adaptive optics imaging in the JHK near-infrared (NIR) in 2014 by Boyajian et al. (2016). The closeness of the star to KIC 8462852 suggested that the two could constitute a binary, which might have implications for the cause of the brightness dips seen by Kepler and in ground-based optical studies. Here, NIR imaging in 2017 using the Mimir instrument resolved the pair and enabled measuring their separation. The faint star had moved 67 ± 7 milliarcsec (mas) relative to KIC 8462852 since 2014. The relativemore »proper motion of the faint star is 23.9 ± 2.6 mas yr-1, for a tangential velocity of 45 ± 5 km s-1 if it is at the same 390 pc distance as KIC 8462852. Circular velocity at the 750 au current projected separation is 1.5 km s-1, hence the star pair cannot be bound.« less
  4. Free, publicly-accessible full text available July 7, 2023