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Isomerization of Aziridines to Allyl Amines via Titanium and Chromium Cooperative Catalysis

https://doi.org/10.1021/acs.joc.1c03054

Yao, Chengbo; Williams, Alana D.; Gu, Yiting; Norton, Jack R. (April 2022, The Journal of Organic Chemistry)

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Synthesis, Characterization, and Catalytic Activity of Bimetallic Ti/Cr Complexes

https://doi.org/10.1021/acs.organomet.0c00645

Chen, Jiawei; Vibbert, Hunter B; Yao, Chengbo; Bartholomew, Amymarie K; Aydt, Alexander P; Jockusch, Steffen; Norton, Jack R; Hammond, Matthew; Rauch, Michael (December 2020, Organometallics)

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Anti-Markovnikov alcohols via epoxide hydrogenation through cooperative catalysis

https://doi.org/10.1126/science.aaw3913

Yao, Chengbo; Dahmen, Tobias; Gansäuer, Andreas; Norton, Jack (May 2019, Science)

The opening of epoxides typically requires electrophilic activation, and subsequent nucleophilic (S N 2) attack on the less substituted carbon leads to alcohols with Markovnikov regioselectivity. We describe a cooperative catalysis approach to anti-Markovnikov alcohols by combining titanocene-catalyzed epoxide opening with chromium-catalyzed hydrogen activation and radical reduction. The titanocene enforces the anti-Markovnikov regioselectivity by forming the more highly substituted radical. The chromium catalyst sequentially transfers a hydrogen atom, proton, and electron from molecular hydrogen, avoiding a hydride transfer to the undesired site and resulting in 100% atom economy. Each step of the interconnected catalytic cycles was confirmed separately.
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