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The reaction of hydropersulfides (RSSH) with S-nitrosothiols (RS-NO) and the biological/physiological implications

https://doi.org/10.1016/j.freeradbiomed.2022.06.245

Zarenkiewicz, Jessica ; Perez-Ternero, Christina ; Kojasoy, Volga ; McGinity, Christopher ; Khodade, Vinayak S. ; Lin, Joseph ; Tantillo, Dean J. ; Toscano, John P. ; Hobbs, Adrian J. ; Fukuto, Jon M. ( August 2022 , Free Radical Biology and Medicine)

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Hydropersulfides (RSSH) and Nitric Oxide (NO) Signaling: Possible Effects on S-Nitrosothiols (RS-NO)

https://doi.org/10.3390/antiox11010169

Fukuto, Jon M. ; Perez-Ternero, Cristina ; Zarenkiewicz, Jessica ; Lin, Joseph ; Hobbs, Adrian J. ; Toscano, John P. ( January 2022 , Antioxidants)

S-Nitrosothiol (RS-NO) formation in proteins and peptides have been implicated as factors in the etiology of many diseases and as possible regulators of thiol protein function. They have also been proposed as possible storage forms of nitric oxide (NO). However, despite their proposed functions/roles, there appears to be little consensus regarding the physiological mechanisms of RS-NO formation and degradation. Hydropersulfides (RSSH) have recently been discovered as endogenously generated species with unique reactivity. One important reaction of RSSH is with RS-NO, which leads to the degradation of RS-NO as well as the release of NO. Thus, it can be speculated that RSSH can be a factor in the regulation of steady-state RS-NO levels, and therefore may be important in RS-NO (patho)physiology. Moreover, RSSH-mediated NO release from RS-NO may be a possible mechanism allowing RS-NO to serve as a storage form of NO.
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Solid-gas reactions for nitroxyl (HNO) generation in the gas phase

https://doi.org/10.1016/j.jinorgbio.2021.111535

Carrone, Guillermo ; Mazzeo, Agostina ; Marceca, Ernesto ; Pellegrino, Juan ; Suárez, Sebastián ; Zarenkiewicz, Jessica ; Toscano, John P. ; Doctorovich, Fabio ( October 2021 , Journal of Inorganic Biochemistry)

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Reaction of Nitroxyl (HNO) with Hydrogen Sulfide and Hydropersulfides

https://doi.org/10.1021/acs.joc.0c02412

Zarenkiewicz, Jessica ; Khodade, Vinayak S. ; Toscano, John P. ( January 2021 , The Journal of Organic Chemistry)
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