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Abstract Motivated by recent experimental observations of opposite Chern numbers in R-type twisted MoTe₂and WSe₂homobilayers, we perform large-scale density-functional-theory calculations with machine learning force fields to investigate moiré band topology across a range of twist angles in both materials. We find that the Chern numbers of the moiré frontier bands change sign as a function of twist angle, and this change is driven by the competition between moiré ferroelectricity and piezoelectricity. Our large-scale calculations, enabled by machine learning methods, reveal crucial insights into interactions across different scales in twisted bilayer systems. The interplay between atomic-level relaxation effects and moiré-scale electrostatic potential variation opens new avenues for the design of intertwined topological and correlated states, including the possibility of mimicking higher Landau level physics in the absence of magnetic field. 

Night-side chorus waves are often observed during plasma sheet injections, typically confined around the equator and thus potentially responsible for precipitation of ≲ 100𝑘𝑒𝑉 electrons. However, recent low-altitude observations have revealed the critical role of chorus waves in scattering relativistic electrons on the night-side. This study presents a night-side relativistic electron precipitation event induced by chorus waves at the strong diffusion regime, as observed by the ELFIN CubeSats. Through event-based modeling of wave propagation under ducted or unducted regimes, we show that a density duct is essential for guiding chorus waves to high latitudes with minimal damping, thus enabling the strong night-side relativistic electron precipitation. These findings underline both the existence and the important role of density ducts in facilitating night-side relativistic electron precipitation. 

Abstract The burgeoning field of semiconductor‐mediated organic conversion is of paramount significance, with zinc indium sulfide (ZnIn₂S₄) emerging as a standout candidate owing to its benign nature, optimal bandgap, extensive light absorption spectrum, remarkable physicochemical properties, and straightforward synthesis. This review examines the latest breakthroughs and the trajectory of ZnIn₂S₄‐based photocatalysts in the realm of selective organic transformation. We start with a distinct overview of the intrinsic physical attributes of ZnIn₂S₄and the underlying mechanisms driving its efficacy in photocatalytic organic transformations. Subsequently, the preparation methods of ZnIn₂S₄are summarized. The main focus is the state‐of‐the‐art photocatalytic application of various ZnIn₂S₄‐based photocatalysts, such as redox reactions, the construction of C−C, C−S and S−S bonds, and the cleavage of C−O, C−C, and C=C bonds. In the conclusion part, we provide our perspectives on the prospective advancements and the remaining challenges that lie ahead in the optimization of ZnIn₂S₄‐based photocatalysts, with the ultimate goal of enhancing their efficacy for a diverse array of photosynthetic applications. It is anticipated to inspire the strategic engineering of ZnIn₂S₄and other semiconductor‐based photocatalysts for various artificial photosynthesis reactions. 

AbstractSickle cell disease (SCD) is canonically characterized by reduced red blood cell (RBC) deformability, leading to microvascular obstruction and inflammation. Although the biophysical properties of sickle RBCs are known to influence SCD vasculopathy, the contribution of poor RBC deformability to endothelial dysfunction has yet to be fully explored. Leveraging interrelated in vitro and in silico approaches, we introduce a new paradigm of SCD vasculopathy in which poorly deformable sickle RBCs directly cause endothelial dysfunction via mechanotransduction, during which endothelial cells sense and pathophysiologically respond to aberrant physical forces independently of microvascular obstruction, adhesion, or hemolysis. We demonstrate that perfusion of sickle RBCs or pharmacologically-dehydrated healthy RBCs into small venule-sized “endothelialized” microfluidics leads to pathologic physical interactions with endothelial cells that directly induce inflammatory pathways. Using a combination of computational simulations and large venule-sized endothelialized microfluidics, we observed that perfusion of heterogeneous sickle RBC subpopulations with varying deformability, as well as suspensions of dehydrated normal RBCs admixed with normal RBCs, leads to aberrant margination of the less-deformable RBC subpopulations toward the vessel walls, causing localized, increased shear stress. Increased wall stress is dependent on the degree of subpopulation heterogeneity and oxygen tension and leads to inflammatory endothelial gene expression via mechanotransductive pathways. Our multifaceted approach demonstrates that the presence of sickle RBCs with reduced deformability leads directly to pathological physical (ie, direct collisions and/or compressive forces) and shear-mediated interactions with endothelial cells and induces an inflammatory response, thereby elucidating the ubiquity of vascular dysfunction in SCD. 

Abstract The two most important wave modes responsible for energetic electron scattering to the Earth's ionosphere are electromagnetic ion cyclotron (EMIC) waves and whistler‐mode waves. These wave modes operate in different energy ranges: whistler‐mode waves are mostly effective in scattering sub‐relativistic electrons, whereas EMIC waves predominately scatter relativistic electrons. In this study, we report the direct observations of energetic electron (from 50 keV to 2.5 MeV) scattering driven by the combined effect of whistler‐mode and EMIC waves using ELFIN measurements. We analyze five events showing EMIC‐driven relativistic electron precipitation accompanied by bursts of whistler‐driven precipitation over a wide energy range. These events reveal an enhancement of relativistic electron precipitation by EMIC waves during intervals of whistler‐mode precipitation compared to intervals of EMIC‐only precipitation. We discuss a possible mechanism responsible for such precipitation. We suggest that below the minimum resonance energy (E_min) of EMIC waves, the whistler‐mode wave may both scatter electrons into the loss‐cone and accelerate them to higher energy (1–3 MeV). Electrons accelerated aboveE_minresonate with EMIC waves that, in turn, quickly scatter those electrons into the loss‐cone. This enhances relativistic electron precipitation beyond what EMIC waves alone could achieve. We present theoretical support for this mechanism, along with observational evidence from the ELFIN mission. We discuss methodologies for further observational investigations of this combined whistler‐mode and EMIC precipitation. 

Abstract Chorus subpackets are the wave packets with modulated amplitudes in chorus waves, commonly observed in the magnetospheres of Earth and other planets. Nonlinear wave‐particle interactions have been suggested to play an important role in subpacket formation, yet the corresponding electron dynamics remain not fully understood. In this study, we have investigated the electron trapping through cyclotron resonance with subpackets, using a self‐consistent general curvilinear plasma simulation code simulation model in dipole fields. The electron trapping period has been quantified separately through electron dynamic analysis and theoretical derivation. Both methods indicate that the electron trapping period is shorter than the subpacket period/duration. We have further established the relation between electron trapping period and subpacket period through statistical analysis using simulation and observational data. Our study demonstrates that the nonlinear electron trapping through cyclotron resonance is the dominant mechanism responsible for subpacket formation. 

A novel drug delivery system hitchhiking albumin as a drug carrier with tuneable redox-responsive drug release.