Disruption of pulmonary vascular homeostasis is a central feature of viral pneumonia, wherein endothelial cell (EC) death and subsequent angiogenic responses are critical determinants of the outcome of severe lung injury. A more granular understanding of the fundamental mechanisms driving reconstitution of lung endothelium is necessary to facilitate therapeutic vascular repair. Here, we demonstrated that TGF-β signaling through TGF-βR2 (transforming growth factor–β receptor 2) is activated in pulmonary ECs upon influenza infection, and mice deficient in endothelial
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Tgfbr2 exhibited prolonged injury and diminished vascular repair. Loss of endothelialTgfbr2 prevented autocrineVegfa (vascular endothelial growth factor α) expression, reduced endothelial proliferation, and impaired renewal of aerocytes thought to be critical for alveolar gas exchange. Angiogenic responses through TGF-βR2 were attributable to leucine-rich α-2-glycoprotein 1, a proangiogenic factor that counterbalances canonical angiostatic TGF-β signaling. Further, we developed a lipid nanoparticle that targets the pulmonary endothelium, Lung-LNP (LuLNP). Delivery ofVegfa mRNA, a critical TGF-βR2 downstream effector, by LuLNPs improved the impaired regeneration phenotype of ECTgfbr2 deficiency during influenza injury. These studies defined a role for TGF-βR2 in lung endothelial repair and demonstrated efficacy of an efficient and safe endothelial-targeted LNP capable of delivering therapeutic mRNA cargo for vascular repair in influenza infection.Free, publicly-accessible full text available January 31, 2025 -
Shen, Jingdong ; Jiang, Wenxiang ; Zhu, Fengfeng ; Wang, Guan-yong ; Li, Huayao ; Zhao, Gan ; Li, Qian ; Yan, Wensheng ; Yang, Wanli ; Chuang, Yi-De ; et al ( , Physical Review B)
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Xue, Lulu ; Gong, Ningqiang ; Shepherd, Sarah J. ; Xiong, Xinhong ; Liao, Xueyang ; Han, Xuexiang ; Zhao, Gan ; Song, Chao ; Huang, Xisha ; Zhang, Hanwen ; et al ( , Journal of the American Chemical Society)