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Abstract DNA origami information storage is a promising alternative to silicon-based data storage, offering a molecular cryptography technique concealing information within DNA origami. Routing, sliding, and interlacing staple strands lead to a large 700-bit key size. Practical DNA data storage requires high information density, robust security, and accurate and rapid information retrieval. Consequently, advanced readout techniques and large encryption key sizes are essential. Here, we report an enhanced DNA origami cryptography protocol in 2D and 3D DNA origami, increasing the encryption key size. We employ all-DNA-based steganography with fast readout through high-speed DNA-PAINT super-resolution imaging. By combining DNA-PAINT data with unsupervised clustering, we achieve an accuracy of up to 89%, despite the flexibility in the 3D DNA origami shown by oxDNA simulation. Furthermore, we propose criteria that ensure complete information retrieval for the DNA origami cryptography. Our findings show that DNA-based cryptography is a secure and versatile solution for storing information. 

The real-world application of image compressive sensing is largely limited by the lack of standardization in implementation and evaluation. To address this limitation, we present OpenICS, an image compressive sensing toolbox that implements multiple popular image compressive sensing algorithms into a unified framework with a standardized user interface. Furthermore, a corresponding benchmark is also proposed to provide a fair and complete evaluation of the implemented algorithms. We hope this work can serve the growing research community of compressive sensing and the industry to facilitate the development and application of image compressive sensing.