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  1. The family of lysine acetyltransferases (KATs) regulates epigenetics and signaling pathways in eukaryotic cells. So far, knowledge of different KAT members contributing to the cellular acetylome is limited, which limits our understanding of biological functions of KATs in physiology and disease. Here, we found that a clickable acyl-CoA reporter, 3-azidopropanoyl CoA (3AZ-CoA), presented remarkable cell permeability and effectively acylated proteins in cells. We rationally engineered the major KAT member, histone acetyltransferase 1 (HAT1), to generate its mutant forms that displayed excellent bio-orthogonal activity for 3AZ-CoA in substrate labeling. We were able to apply the bio-orthogonal enzyme–cofactor pair combined with SILACmore »proteomics to achieve HAT1 substrate targeting, enrichment, and proteomic profiling in living cells. A total of 123 protein substrates of HAT1 were disclosed, underlining the multifactorial functions of this important enzyme than hitherto known. This study demonstrates the first example of utilizing bio-orthogonal reporters as a chemoproteomic strategy for substrate mapping of individual KAT isoforms in the native biological contexts.« less
    Free, publicly-accessible full text available April 13, 2023
  2. Free, publicly-accessible full text available January 1, 2023
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  6. We show how to interpret logarithmic spiral tilings as one-dimensional particle systems undergoing inelastic collapse. By deforming the spirals appropriately, we can simulate collisions among particles with distinct or varying coefficients of restitution. Our geometric constructions provide a strikingly simple illustration of a widely studied phenomenon in the physics of dissipative gases: the collapse of inelastic particles.
  7. This paper proposes a low-latency FPGA implemen-tation for Turbo equalization to combat very long multipathfading channels where the Intersymbol-interference (ISI) channellength is on the order of 100 taps. Turbo equalization is essentialfor such severe multipath channels, but exhibits very large latencyand high computational complexity due to its sequential anditerative data processing on large-scale matrix arithmetic. Thispaper proposes an FPGA acceleration architecture to exploitthe Hermitian symmetric property of the channel Gram matrixand convolutional nature of Sequential Interference Cancellation(SIC), and successfully implements a linear Turbo equalizerof 100 taps on a Xilinx Zynq UltraScale+ MPSoC ZCU102Evaluation Kit. The architecture is able to supportmore »two turboiterations for a 1024-symbol block size and achieve 200 kilo-symbols-per-second (ksps) transmission rate.« less