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Chromatin dynamics and organization can be altered by condensin complexes. In turn, the molecular behavior of a condensin complex changes based on the tension of the substrate to which condensin is bound. This interplay between chromatin organization and condensin behavior demonstrates the need for tools that allows condensin complexes to be observed on a variety of chromatin organizations. We provide a method for simulating condensin complexes on a dynamic polymer substrate using the polymer dynamics simulator ChromoShake and the condensin simulator RotoStep. These simulations can be converted into simulated fluorescent images that are able to be directly compared to experimental images of condensin and fluorescently labeled chromatin. Our pipeline enables users to explore how changes in condensin behavior alters chromatin dynamics and vice versa while providing simulated image datasets that can be directly compared to experimental observations. 

A description is presented of the algorithms used to reconstruct energy deposited in the CMS hadron calorimeter during Run 2 (2015–2018) of the LHC. During Run 2, the characteristic bunch-crossing spacing for proton-proton collisions was 25 ns, which resulted in overlapping signals from adjacent crossings. The energy corresponding to a particular bunch crossing of interest is estimated using the known pulse shapes of energy depositions in the calorimeter, which are measured as functions of both energy and time. A variety of algorithms were developed to mitigate the effects of adjacent bunch crossings on local energy reconstruction in the hadron calorimeter in Run 2, and their performance is compared.

 

A search for decays to invisible particles of Higgs bosons produced in association with a top-antitop quark pair or a vector boson, which both decay to a fully hadronic final state, has been performed using proton-proton collision data collected at$${\sqrt{s}=13\,\text {Te}\hspace{-.08em}\text {V}}$$$\sqrt{s}=13\text{Te}\text{V}$by the CMS experiment at the LHC, corresponding to an integrated luminosity of 138$$\,\text {fb}^{-1}$$${\text{fb}}^{-1}$. The 95% confidence level upper limit set on the branching fraction of the 125$$\,\text {Ge}\hspace{-.08em}\text {V}$$$\text{Ge}\text{V}$Higgs boson to invisible particles,$${\mathcal {B}({\textrm{H}} \rightarrow \text {inv})}$$$B(\text{H}\to \text{inv})$, is 0.54 (0.39 expected), assuming standard model production cross sections. The results of this analysis are combined with previous$${\mathcal {B}({\textrm{H}} \rightarrow \text {inv})}$$$B(\text{H}\to \text{inv})$searches carried out at$${\sqrt{s}=7}$$$\sqrt{s}=7$, 8, and 13$$\,\text {Te}\hspace{-.08em}\text {V}$$$\text{Te}\text{V}$in complementary production modes. The combined upper limit at 95% confidence level on$${\mathcal {B}({\textrm{H}} \rightarrow \text {inv})}$$$B(\text{H}\to \text{inv})$is 0.15 (0.08 expected).