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The paper presents results from a pilot questionnaire-based study on ten Stack Overflow (SO) questions. Eleven developers were tasked with determining if the SO question sentiment was positive, negative or neutral. The results from the questionnaire indicate that developers mostly rated the sentiment of SO questions as neutral, stating that they received little or no emotional feedback from the questions. Tools that were designed to analyze Software Engineering related texts (SentiStrength-SE, SentiCR, and Senti4SD) were on average more closely aligned with developer ratings for a majority of the questions than general purpose tools for detecting SO question sentiment. We discuss cases where tools and developer sentiment differ along with implications of the results. Overall, the sentiment tool output on the question title and body is more aligned with the developer rating than just the title alone. Since SO is a very common medium of technical exchange, we also report that adding code snippets, short titles, and multiple tags were top three features developers prefer in SO questions in order for it to be answered quickly. 

Program comprehension is a vital skill in software development. This work investigates program comprehension by examining the eye movement of novice programmers as they gain programming experience over the duration of a Java course. Their eye movement behavior is compared to the eye movement of expert programmers. Eye movement studies of natural text show that word frequency and length influence eye movement duration and act as indicators of reading skill. The study uses an existing longitudinal eye tracking dataset with 20 novice and experienced readers of source code. The work investigates the acquisition of the effects of token frequency and token length in source code reading as an indication of program reading skill. The results show evidence of the frequency and length effects in reading source code and the acquisition of these effects by novices. These results are then leveraged in a machine learning model demonstrating how eye movement can be used to estimate programming proficiency and classify novices from experts with 72% accuracy. 

Eye tracking tools are used in software engineering research to study various software development activities. However, a major limitation of these tools is their inability to track gaze data for activities that involve source code editing. We present a novel solution to support eye tracking experiments for tasks involving source code edits as an extension of the iTrace community infrastructure. We introduce the iTrace-Atom plugin and gazel—a Python data processing pipeline that maps gaze information to changing source code elements and provides researchers with a way to query this dynamic data. iTrace-Atom is evaluated via a series of simulations and is over 99% accurate at high eye-tracking speeds of over 1,000Hz. iTrace and gazel completely revolutionize the way eye tracking studies are conducted in realistic settings with the presence of scrolling, context switching, and now editing. This opens the doors to support many day-to-day software engineering tasks such as bug fixing, adding new features, and refactoring. 

Polyglot programming, the use of multiple programming languages during the development process, is common practice in modern software development. This study investigates this practice through a randomized controlled trial conducted under the context of database programming. Participants in the study were given coding tasks written in Java and one of three SQL-like embedded languages. One was plain SQL in strings, one was in Java only, and the third was a hybrid embedded language that was closer to the host language. We recorded 109 valid data points. Results showed significant differences in how developers of different experience levels code using polyglot techniques. Notably, less experienced programmers wrote correct programs faster in the hybrid condition (frequent, but less severe, switches), while more experienced developers that already knew both languages performed better in traditional SQL (less frequent, but more complete, switches). The results indicate that the productivity impact of polyglot programming is complex and experience level dependent. 

Studies of eye movements during source code reading have supported the idea that reading source code differs fundamentally from reading natural text. The paper analyzed an existing data set of natural language and source code eye movement data using the E-Z reader model of eye movement control. The results show that the E-Z reader model can be used with natural text and with source code where it provides good predictions of eye movement duration. This result is confirmed by comparing model predictions to eye-movement data from this experiment and calculating the correlation score for each metric. Finally, it was found that gaze duration is influenced by token frequency in code and in natural text. The frequency effect is less pronounced on first fixation duration and single fixation duration. An eye movement control model for source code reading may open the door for tools in education and the industry to enhance program comprehension. 

Stack Overflow is commonly used by software developers to help solve problems they face while working on software tasks such as fixing bugs or building new features. Recent research has explored how the content of Stack Overflow posts affects attraction and how the reputation of users attracts more visitors. However, there is very little evidence on the effect that visual attractors and content quantity have on directing gaze toward parts of a post, and which parts hold the attention of a user longer. Moreover, little is known about how these attractors help developers (students and professionals) answer comprehension questions. This paper presents an eye tracking study on thirty developers constrained to reading only Stack Overflow posts while summarizing four open source methods or classes. Results indicate that on average paragraphs and code snippets were fixated upon most often and longest. When ranking pages by number of appearance of code blocks and paragraphs, we found that while the presence of more code blocks did not affect number of fixations, the presence of increasing numbers of plain text paragraphs significantly drove down the fixations on comments. SO posts that were looked at only by students had longer fixation times on code elements within the first ten fixations. We found that 16 developer summaries contained 5 or more meaningful terms from SO posts they viewed. We discuss how our observations of reading behavior could benefit how users structure their posts. 

Most cell penetrating peptides (CPPs) are unstructured and susceptible to proteolytic degradation. One alternative is to incorporate D‐chirality amino acids into unstructured CPPs to allow for enhanced uptake and intracellular stability. This work investigates CPP internalization using a series of time, concentration, temperature, and energy dependent studies, resulting in a three‐fold increase in uptake and 50‐fold increase in stability of D‐chirality peptides over L‐chirality counterparts. CPP internalization occurred via a combination of direct penetration and endocytosis, with a percentage of internalized CPP expelling from cells in a time‐dependent manner. Mechanistic studies identified that cells exported the intact internalized D‐chirality CPPs via an exocytosis independent pathway, analogous to a direct penetration method out of the cells. These findings highlight the potential of a D‐chirality CPP as bio‐vector in therapeutic and biosensing applications, but also identify a new expulsion method suggesting a relationship between uptake kinetics, intracellular stability, and export kinetics.