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Variability in the strength of low-cloud feedbacks across climate models is the primary contributor to the spread in their estimates of equilibrium climate sensitivity (ECS). This raises the question: What are the regional implications for key features of tropical climate of globally weak versus strong low-cloud feedbacks in response to greenhouse gas–induced warming? To address this question and formalize our understanding of cloud controls on tropical climate, we perform a suite of idealized fully coupled and slab-ocean climate simulations across which we systematically scale the strength of the low-cloud-cover feedback under abrupt 2 × CO₂forcing within a single model, thereby isolating the impact of low-cloud feedback strength. The feedback strength is varied by modifying the stratus cloud fraction so that it is a function of not only local conditions but also global temperature in a series of abrupt 2 × CO₂sensitivity experiments. The unperturbed decrease in low cloud cover (LCC) under 2 × CO₂is greatest in the mid- and high-latitude oceans, and the subtropical eastern Pacific and Atlantic, a pattern that is magnified as the feedback strength is scaled. Consequently, sea surface temperature (SST) increases more in these regions as well as the Pacific cold tongue. As the strength of the low-cloud feedback increases this results in not only increased ECS, but also an enhanced reduction of the large-scale zonal and meridional SST gradients (structural climate sensitivity), with implications for the atmospheric Hadley and Walker circulations, as well as the hydrological cycle. The relevance of our results to simulating past warm climate is also discussed.