skip to main content


Search for: All records

Creators/Authors contains: "Ghosh, Goutam"

Note: When clicking on a Digital Object Identifier (DOI) number, you will be taken to an external site maintained by the publisher. Some full text articles may not yet be available without a charge during the embargo (administrative interval).
What is a DOI Number?

Some links on this page may take you to non-federal websites. Their policies may differ from this site.

  1. Abstract

    With interests in alkoxy radical formation on natural and artificial surfaces, a physical‐organic study was carried out with a Hammett series of triaryl phosphites (p‐MeO, H,p‐F, andp‐Cl) to trap adsorbed alkoxy radicals on silica nanoparticles. A mechanism which involves PhC (Me)2O• and EtO• trapping in a cumylethyl peroxide sensitized homolysis reaction is consistent with the results. Thep‐F phosphite was able to indirectly monitor the alkoxy radical formation, and31P NMR readily enabled this exploration, but other phosphites of the series such as thep‐MeO phosphite were limited by hydrolysis reactions catalyzed by surface silanol groups. Fluorinated silica nanoparticles helped to suppress the hydrolysis reaction although adventitious water also plays a role in hindering efficient capture of the alkoxy radicals by the phosphite traps.

     
    more » « less
  2. Abstract

    The sensitized photooxidation ofortho‐prenyl phenol is described with evidence that solvent aproticity favors the formation of a dihydrobenzofuran [2‐(prop‐1‐en‐2‐yl)‐2,3‐dihydrobenzofuran], a moiety commonly found in natural products. Benzene solvent increased the total quenching rate constant (kT) of singlet oxygen with prenyl phenol by ~10‐fold compared to methanol. A mechanism is proposed with preferential addition of singlet oxygen to prenyl site due to hydrogen bonding with the phenol OH group, which causes a divergence away from the singlet oxygen ‘ene’ reaction toward the dihydrobenzofuran as the major product. The reaction is a mixed photooxidized system since an epoxide arises by a type I sensitized photooxidation.

     
    more » « less
  3. Abstract

    Ru(II) complexes were synthesized with π‐expanding (phenyl, fluorenyl, phenanthrenyl, naphthalen‐1‐yl, naphthalene‐2‐yl, anthryl and pyrenyl groups) attached at a 1H‐imidazo[4,5‐f][1,10]phenanthroline ligand and 4,4′‐dimethyl‐2,2′‐bipyridine (4,4′‐dmb) coligands. These Ru(II) complexes were characterized by 1D and 2D NMR, and mass spectroscopy, and studied for visible light and dark toxicity to human malignant melanoma SK‐MEL‐28 cells. In the SK‐MEL‐28 cells, the Ru(II) complexes are highly phototoxic (EC50 = 0.2–0.5 µm) and have low dark toxicity (EC50 = 58–230 µm). The highest phototherapeutic index (PI) of the series was found with the Ru(II) complex bearing the 2‐(pyren‐1‐yl)‐1H‐imidazo[4,5‐f][1,10]phenanthroline ligand. This high PI is in part attributed to the π‐rich character added by the pyrenyl group, and a possible low‐lying and longer‐lived3IL state due to equilibration with the3MLCT state. While this pyrenyl Ru(II) complex possessed a relatively high quantum yield for singlet oxygen formation (Φ = 0.84), contributions from type‐I processes (oxygen radicals and radical ions) are competitive with the type‐II (1O2) process based on effects of added sodium azide and solvent deuteration.

     
    more » « less